The best-known treatment is liver replacement to slow the production of TTR protein (2,5).Any form of amyloidosis (AL, AA or ATTR) is very rare and extremely life threatening. There is no cure. Patients have an average life expectancy of about 1 to 1 1/2 years from the time of ...
免疫球蛋白轻链型淀粉样变性(immunoglobulin lightchain amyloidosis,AL)是最为常见的淀粉样变性类型。引起AL淀粉样变性的蛋白为单克隆免疫球蛋白轻链或轻链片段,机制在于其被免疫系统视为机体正常组成成分,从而逃避免疫系统攻击。单克隆免疫球蛋白轻链或轻链片...
刘肥: Light Chain 榜荐辆苞 悼馆等 蜡傈盒刘 1 抗 lmmunoglobolin-related or primary amyloidosis has been reported to develop in 6 to 15% of patients with multiple myeloma and especially in 20 to 24% of pat... 捞康帮,捞侩盔,弥柳疙,... - 《Korean Journal of Medicine:备 措茄郴苞...
Primary systemic amyloidosis (AL), a disease involving the deposition of immunoglobulin light chains in tissue, is caused by a plasma cell dyscrasia. In the case of amyloidosis reported here, no monoclonal component was seen upon routine protein electrophoresis of serum or urine nor was a bone ...
目的:通过报道1例以皮肤紫癜和肾损害为主要临床表现的免疫球蛋白轻链κ亚型淀粉样变性病(immunoglobulin light-chain kappa subtypes amyloidosis)的病例,并结合文献... 包红梅,郭文岗,任稹,... - 《临床肾脏病杂志》 被引量: 0发表: 2014年 轻链型心肌淀粉样变性心肌核素显像阳性1例 病史摘要患者,女性,51岁,主...
Free light chainsHaematologic responseAL amyloidosis is caused by the conversion of monoclonal immunoglobulin light chains into amyloid fibrillar aggregates that ... A Jaccard,F Bridoux - 《Nephrologie & Therapeutique》 被引量: 0发表: 2019年 Philadelphia chromosome positive B-cell type malignant lymph...
serum total light chain sFLC: serum free light chain ROC: Receiver operating characteristic AUC: area under the curve SPE: serum protein electrophoresis sIFE: serum immunofixation electrophoresis MGUS: monoclonal gammopathy of undetermined significance AL: Immunoglobulin light chain amyloidosis ...
Ratio FLC value (kappa FLC/lambda FLC) compared to reference ranges may indicate presence of plasma cell disorders disease like Multiple Myeloma or AL amyloidosis in a patient. Nephelometric and turbidimetric based assays have been shown to overestimate the sFLC levels that are not always consistent...
light chains in the blood. If the amount of free light chains is higher or lower than normal, it can mean you have a disorder of the plasma cells. These include multiple myeloma, a cancer of plasma cells, and amyloidosis, a condition that causes a dangerous buildup of proteins in ...
Experimental model of human light-chain-associated disease. The three types of human light-chain-associated disease—"myeloma kidney" disease (myeloma [cast] nephropathy), light-chain deposition disease, and AL amyloidosis—are characterized by renal and systemic deposition of monoclonal light ch... ...