In systemic light-chain amyloidosis, monoclonal antibodies target antigens that are either membrane-bound or circulating or deposited in the organs. CD38 holds high promise as a target against clonal plasma cells. Multiple anti-CD38 antibodies are either approved for use or being investigated in ...
New criteria for response to treatment in immunoglobulin light chain amyloidosis based on free light chain measurement and cardiac biomarkers: impact on survival outcomes. J Clin Oncol 2012; 30: 4541–4549. Article CAS Google Scholar Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D...
The relationship between the kappa positive reaction of amyloid and its resistance to induced proteolysis are discussed. 展开 关键词: Primary amyloidosis Monoclonal gammopathy Kappa light chain positivity DOI: 10.1007/BF00695235 被引量: 7 年份: 1984 ...
Systemic light chain amyloidosis: an update for treating physicians Blood, 121 (2013), pp. 5124-5130 Google Scholar 33. H.J. Lachmann, D.R. Booth, S.E. Booth, et al. Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis N Engl J Med, 346 (2002), pp. 1786-1791 Google...
The two light-chain types are kappa (κ) and lambda (λ). A polyclonal gammopathy is characterized by an increase in one or more heavy chains and in both types of light chain. One must differentiate between a monoclonal and a polyclonal increase in immunoglobulins, because a monoclonal ...
Mandreoli M, Casanova S, Vianelli N, et al. Remission of nephrotic syndrome due to AA amyloidosis and initiation of glomerular repair after surgical resection of localized Castleman’s disease. Nephron. 2002;90(3):336–40. ArticlePubMedGoogle Scholar ...
The paraprotein can be found as an intact immunoglobulin, only light chains (light chain myeloma, light chain deposition disease, or amyloid light chain amyloidosis), or, rarely, only as heavy chains (heavy chain disease). Paraproteins can be detected in the serum and can also be ...
hereditary spherocytosis, thalassemia, autoimmune disease–eg, glomerulonephritis, pemphigus vulgaris, scleroderma, liver disease, kidney disease, amyloidosis, acute porphyria, chronic salpingitis, systemic capillary leak syndrome, Gaucher's disease, uterine fibromas, cerebrovascular disease, ASHD. See Hybridom...
The term monoclonal gammopathy of undetermined significance (MGUS) denotes the presence of a monoclonal protein (M protein) in persons without evidence of multiple myeloma (MM), Waldenström’s macroglobulinemia (WM), AL amyloidosis (AL), or other related diseases. MGUS is characterized by a seru...
A novel mass spectrometry method to identify the serum monoclonal light chain component in systemic light chain amyloidosisdoi:10.1038/s41408-019-0180-1Faye A. SharpleyRicha ManwaniShameem MahmoodSajitha SachchithananthamHelen J. LachmannJulian D. Gillmore...