2.Zeng, W., et al., Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity. Cell, 2010. 141(2): p. 315-30. 3.Peisley, A., et al., Structural basis...
抗体名: Purified anti-Polyubiquitin (K63-linkage) Antibody 亚型: Mouse IgG2a, λ 浓度: 0.5 mg/ml % 是否单克隆: 是 靶点: 科研研究 免疫原: Synthetic peptide containing the ubiquitin K-63 isopeptide motif 用途: 科研研究 宿主: 小鼠 保质期: 科研研究 应用范围: WB, IHC-F, ICC, IP...
A ubiquitin-binding CUE domain in presenilin-1 enables interaction with K63-linked polyubiquitin chains. FEBS Lett 2015; 589: 1001-1008.S.P. Duggan, R. Yan, J.V. McCarthy, A ubiquitin-binding CUE domain in presenilin-1 enables interaction with K63-linked polyubiquitin chains, FEBS Lett. ...
Biotin K63-TUBE consists of multiple ubiquitin interacting motifs separated by rigid linkers, presumably increasing its affinity to extended K63 polyubiquitin chains. Biotin K63-TUBE is useful for detection and characterization of K63-linked polyubiquitylated proteins by Far Western blotting, affinity pu...
Modification of proteins by addition of K63-linked polyubiquitin chains is implicated in a variety of cellular events, including DNA repair, signal transduction and receptor endocytosis. A monoclonal antibody (mAb) has been generated that specifically recognizes K63-linked polyubiquitin chains, but not...
2023年8月15日,山东大学基础医学院高成江教授团队在Cellular & Molecular Immunology杂志发表题为MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate the RIG-I-MAVS signaling cascade的研究成果。报道了MAVS承载的非锚定K63...
NEMO itself is modified by the K63-linked polyubiquitin chains. It remains open whether NEMO can bind to itself through these conjugated K63-linked polyubiquitin chains to form oligomers of IKK complex. Previous studies indicated that NEMO could form a dimer, trimer or tetramer in vivo and in ...
This functional diversity of polyubiquitin chains is re-ferred to as the ubiquitin code (4). Among the eight ubiquitinlinkages, the K48 and K63 linkages are most abundant, ac-counting for approximately 80% of the total linkages in mam-malian cells (5). K48-linked ubiquitin chains are the...
This domain binds efficiently to K63-linked poly-ubiquitin chains within a narrow range of chain lengths but not to K48-linked poly-ubiquitin chains. Other syntaxin family members also bind to K63-linked polyubiquitin chains but with different chain length specificities. Molecular modeling suggests ...
技术支持 货号14-6077-82 Price (CNY) 4,442.00 下单后预计有货时间 16-May-2025 查看价格 批量或定制请求 抗体检测数据 (1) 已发表图片 (2) Application Created with Sketch. 图:1/3 Ub-K63 Antibody (14-6077-82) in WB In vitro linked and purified polyubiquitin chains were analyzed by SDS-PAGE...