Here we describe the presence of a CUE ubiquitin-binding domain in the hydrophilic loop domain of presenilins, which facilitates an interaction between PS1 and K63-linked polyubiquitin chains. Despite the signi
Polyubiquitin chainlinkages are critical determinants that direct substrates to dis-tinct pathways, a concept referred to as the ubiquitin code.Lysine-63 (K63)-linked polyubiquitin chains are the secondmost abundant linkage type in cells, and are known to regulateproteasome-independent pathways such ...