Strung up with the revolutionary Dark Matter Damping and Titanal I-Beam construction, the Disruption 78Ti can arc like nothing you’ve ever experienced.In line with the rest of the Disruption collection, these are made for downhill charging, with maximum control and maneuverability.From the firmn...
The anterior cingulate cortex (ACC) is a brain area involved in modulating behavior associated with social interaction, disruption of which is a core feature of autism spectrum disorder (ASD). Functional brain imaging studies demonstrate abnormalities of the ACC in ASD as compared to typically develo...
D. et al. Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity. Science 353, 399–403 (2016). Article ADS CAS PubMed PubMed Central Google Scholar Zou, W. P., Wolchok, J. D. & Chen, L. P. PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy...
In addition, this hypothesis also predicts that selective disruption of thalamic K2P channels in vivo may produce a similar sleep phenotype to that seen in the TASK-3 global knockout. In comparison to the study of K2Ps and sleep, the study of K2P channels in anaesthesia has advanced much ...
agonist stimulation of β2AR caused delayed turnover of GRK2 and up-regulation of global kinase levels in HEK293 cells through a mechanism involving PKA-mediated phosphorylation of DDB1 and disruption of Gβ2 binding to DDB1-Cul4A ligase. This mechanism of feedback regulation and GRK2 stabiliz...
LMTK2 levels are reduced in cortex but not cerebellum of Alzheimer's disease patients Disruption to axonal transport is a major pathogenic event in Alzheimer's disease [2, 5, 9, 30, 55]. Since siRNA loss of LMTK2 perturbed axonal transport of both p35 and cdk5, we enquired whether LMTK2...
Some studies point to a lack of kinase activity and mislocalization of mutated TTBK2, while others reported a disruption of normal TTBK2 function caused by SCA11 alleles, particularly during ciliogenesis. Although TTBK2 has a proven function in cilia formation, the phenotype caused by heterozygous...
While, originally, Bartters’ syndrome was largely attributable to the disruption of NaCl reabsorption in the thick ascending limb and resistance to loop diuretic furosemide [64,69], animal knockout models also exhibited a dramatic reduction of salt reabsorption in the distal convoluted tubule and ...