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重组人泛素-K0蛋白产品,又称0.其对应NCBI基因号为6233,对应Accession号为P62979. 来源宿主 提供的【Ubiquitin K0】重组人泛素-K0产品的来源为大肠杆菌重组表达. 溶解建议 重组人泛素-K0产品为液体即用型,其溶液组成为:4 mg/ml in PBS. 保存建议 在您收到艾美捷发出的【Ubiquitin K0】重组人泛素-K0产品后,建议...
Effects of K0 and K63only ubiquitin mutants on stalled translation.Kazuki SaitoWataru HorikawaKoichi Ito
There are two major degradation pathways to rid a cell of unwanted or misfolded proteins to prevent their accumulation and to maintain the health of a cell: the ubiquitin–proteasome system and the autophagy–lysosomal pathway. Both of these degradative pathways depend on the modification of targets...
The autophagic clearance of damaged lysosomes by lysophagy involves extensive modification of the organelle with ubiquitin, but the underlying ubiquitination machinery is still poorly characterized. Here, we use an siRNA screening approach and identify human UBE2QL1 as a major regulator of lysosomal ubiq...
type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription ...
团队将一种被广泛运用的 ALS 细胞模型,SOD1+/4AV 培养在 PA2 上。团队发现与 laminin 培养相比,PA2 培养的突变细胞表现出更多的 SOD1 与 ubiquitin 蛋白聚集,而这正是 ALS 发病的组织学特征之一。 文章另一位通讯作者 Kiskinis 博士...
[2]Craig K L, Tyers M.The F-box:A New Mot if for Ubiquitin De-pendent Proteolysis in Cell Cycle Regulation and Signal Transduc-tion[J].Prog Biophys Mol Biol, 1999, 72 (3) :299-328. [3]Callis J, Vierstra R D.Protein Degradation in Signaling[J].Curr Opin Plant Biol, 2000, 3 ...