Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8(+) T cell exhaustion. Immunity. 2016;45(2):358–73. Article CAS PubMed PubMed Central Google Scholar Wolf Y, Anderson AC, Kuchroo VK. TIM3 comes of age as an...
Evading the immune system using the PD-1/PD-L1 axis is an intelligent way for cancers, and T cells cannot respond fully and confront cancer. Recently, the miR-138 was reported as a PD-L1 regulator in NSCLC. However, its inhibitory impact on T-cell exhaustion has not been characterized. ...
International Journal of Molecular Sciences Article ArtinM Mediates Murine T Cell Activation and Induces Cell Death in Jurkat Human Leukemic T Cells Thiago Aparecido da Silva , Patrícia Kellen Martins Oliveira-Brito, Thiago Eleutério Gonçalves, Patrícia Edivânia Vendruscolo and Maria Cristina ...