Cancer remains a global major health burden. Activation of certain signaling pathways such as Janus kinase (JAK)/signal transducer and activator of transcription (STAT) is found to be an important regulatory defect present in most cancerous cells amongst other factors. The signaling of Cytokine ...
我们可以推测,JAK/STAT信号和这些最近确定的可操作驱动因素之间可能存在合作性的依赖关系,这提高了联合治疗的可能性,以具体和有力地针对这一抗性细胞群。需要做更多的工作来确定JAK/STAT的研究结果如何适用于其他亚型和CRPC过渡到AR漠视的模...
1.Xiaoyi Hu, et al. The JAK/STAT signaling pathway: from bench to clinic. Signal Transduction and Targeted Therapy, 2021. https://doi.org/10.1038/s41392-021-00791-1 2.Szekanecz, et al. Efficacy and safety of JAK i...
JAK(Janus kinase)属于非受体酪氨酸激酶家族,有JAK1、JAK2、JAK3和TYK2四个成员。这些激酶在胞内信号传导中具有关键作用,尤其是细胞因子、生长因子等介导的信号通路,如JAK-STAT。 JAK-STAT在细胞增殖、分化、凋亡以及免疫调控等方面扮演着至关重要的角色。JAK激酶蛋白通过与跨膜受体结合,参与细胞外信号传递,并通过磷...
我们先来看看JAK-STAT通路在kegg通路中的位置。在前文提到的kegg核心35通路中(下图),JAK-STAT通路一共与8个通路存在直接连接。里面包括我们上文提到过的PI3K-Akt通路、MAPK通路,还包括Pathway in cancer。是的,JAK-STAT就是1个在肿瘤中起着重要作用的通路,而且可以通过独特的方式将各个相关通路串联在一起。 图1...
Through a comprehensive review and in silico analysis of reported data on STAT‐linked diseases, we analysed the communication pathways and interactome of the seven STATs in major cancer categories and propos
The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer, and such hyperactivation is generally associated with a poor clinical prognosis. In the tumour microenvironment, IL-6/JAK/STAT3 signalling acts to drive the proliferation, survival, invasiveness, and metastasis of tumou...
Hu X et al. The JAK/STAT signaling pathway: from bench to clinic. Signal Transduct Target Ther. 2021 Nov 26;6(1):402. Yu H et al. Revisiting STAT3 signalling in cancer: new and unexpected biological functions. Nat Rev Cancer. 2014 Nov;14(11):736-46. ...
Hu X et al. The JAK/STAT signaling pathway: from bench to clinic. Signal Transduct Target Ther. 2021 Nov 26;6(1):402. Yu H et al. Revisiting STAT3 signalling in cancer: new and unexpected biological functions. Nat Rev Cancer. 2014 Nov;14(11):736-46. ...
Jiaqi Wang et al. The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway. Molecular Cancer (2021) 20:81 https://doi.org/10.1186/s12943-021-01375-x 版权声明 本网站所有注明“来源:生物谷”或“来源:bioon”的文字、图片和音视频...