Key Points: Question: Is the Worst Itch Numeric Rating Scale (WI-NRS) an appropriate tool for quantifying the intensity of pruritus associated with prurigo nodularis? Findings: This secondary analysis of pooled data from the PRIME and PRIME2 clinical trials found that...
Despite this, tradipitant failed to meet the primary endpoint of reduction of worst itch numeric rating scale (WI-NRS) change in EPIONE, which triggered the commencement of the identical EPIONE2 study that further assesses tradipitant’s anti-pruritic effects in the mild to ...
B244 reduced enrolled patients’ mean Worst Itch Numeric Rating Scale (WI-NRS) score by 34.3% (-2.8 B244 vs -2.1 placebo, p=0.0143 and p=0.0148 for high and low dose) from a baseline WI-NRS score above 8 (out of 10). Secondary...
At week 12, a clinically meaningful improvement in itch [Itch Numeric Rating Scale (NRS) reduction≥4] was seen in 70.0%, 88.6%, and 90.8% of the IXE-treated patients in the baseline Itch NRS 4–6, 7–8, and 9–10 groups, respectively (all itch severity groups p<0.001 versus ETN ...
Validity of a Single Worst Itch Numeric Rating Scale (WI-NRS) Measurement to Identify Patients with Moderate or Severe CKD-Associated Pruritusdoi:10.1681/ASN.2024k64q3cs2Kieran MccaffertyBarts Health NHS Trust, London, London, United Kingdom;Thilo Schaufler...
Objective We conducted supplementary analyses to assess the psychometric properties of the Worst Itch Numeric Rating Scale (WI‐NRS), the TR03 primary endpoint. Methods Study TR03 was a double‐blind, placebo‐controlled, phase 2 trial in PN patients with documented scores ≥5 on the WI‐NRS ...
Objectives: This study investigated the psychometric properties of the Itch Numeric Rating Scale (Itch NRS), a single-item patient-reported outcome (PRO) measuring worst itching severity due to psoriasis in the past 24 hours. Methods: Using disease-specific clinician-rated and PRO data from one ...
The Itch Numeric Rating Scale (I-NRS) was developed as a single item to assess severity of this symptom at its most intense during the previous 24-hour period, with anchors at 0 representing "no itching" and 10 representing "worst itch imaginable." Objectives: To evaluate psychometric ...
Among the most bothersome symptoms, itch has been measured using the Itch Numeric Rating Scale (NRS). This study explored the symptom and impacts of itch with pediatric psoriasis patients and evaluated the content validity of the Itch NRS in children.Mannix, SallyEdson-Heredia, EmilyPaller, Amy...
Objective: To evaluate comprehensibility and reproducibility of the Scalp Itch Numeric Rating Scale (NRS), a novel scale being used in a phase 3 study of apremilast. Methods: The Scalp Itch NRS, Modified Whole Body Itch NRS, Global Assessment of Psoriasis Severity-Scalp (GAPS-S), and Global ...