Key Points: Question: Is the Worst Itch Numeric Rating Scale (WI-NRS) an appropriate tool for quantifying the intensity of pruritus associated with prurigo nodularis? Findings: This secondary analysis of pooled data from the PRIME and PRIME2 clinical trials found that...
B244 reduced enrolled patients’ mean Worst Itch Numeric Rating Scale (WI-NRS) score by 34.3% (-2.8 B244 vs -2.1 placebo, p=0.0143 and p=0.0148 for high and low dose) from a baseline WI-NRS score above 8 (out of 10). Secondary...
Phylogenetic Tree of Avian Schistosome GeneraTrichobilharzia. Tree topology is based on Bayesian Inference. Nodal support is indicated with posterior probabilities (shown by coloured branches and associated numeric probabilities) followed by bootstrap support from Maximum Likelihood. GenBank accession numbers...
At week 12, a clinically meaningful improvement in itch [Itch Numeric Rating Scale (NRS) reduction≥4] was seen in 70.0%, 88.6%, and 90.8% of the IXE-treated patients in the baseline Itch NRS 4–6, 7–8, and 9–10 groups, respectively (all itch severity groups p<0.001 versus ETN ...
In multivariable Poisson regression models, the number of itch triggers was associated with more severe patient-reported global AD severity, Numeric Rating Scale worst itch, Patient-Oriented Eczema Measure, Scoring Atopic Dermatitis sleep, Numeric Rating Scale skin pain, Eczema Area and Severity Index...
Of 126 enrolled patients, 62 were assigned to receive difelikefalin and 63 to receive placebo. The baseline mean score on the Worst Itch Numeric Rating Scale was 7.6 (severe itch) in each group. The reduction from baseline in the worst itch score at week eight was 4.0 points in patients ...
Psychometric properties of the Itch Numeric Rating Scale in patients with moderate-to-severe plaque psoriasis. Br J Dermatol. 2016; 175(1):157-162.Kimball AB, Naegeli AN, Edson-Heredia E, et al. Psychometric properties of the itch numeric rating scale in patients with moderate- to-severe ...
Psychometric properties of the Itch Numeric Rating Scale in patients with moderate-to-severe plaque psoriasis. Br J Dermatol. 2016; 175(1):157-162.Kimball AB, Naegeli AN, Edson-Heredia E, et al. Psychometric properties of the itch numeric rating scale in patients with moderate- to-severe ...
Objective We conducted supplementary analyses to assess the psychometric properties of the Worst Itch Numeric Rating Scale (WI‐NRS), the TR03 primary endpoint. Methods Study TR03 was a double‐blind, placebo‐controlled, phase 2 trial in PN patients with documented scores ≥5 on the WI‐NRS ...
Validity of a Single Worst Itch Numeric Rating Scale (WI-NRS) Measurement to Identify Patients with Moderate or Severe CKD-Associated Pruritusdoi:10.1681/ASN.2024k64q3cs2Kieran MccaffertyBarts Health NHS Trust, London, London, United Kingdom;Thilo Schaufler...