与大多数大肠杆菌表达的重组蛋白或者多肽作为免疫原相比,该免疫原是采用CellFree Science Co, Ltd。 (CFS)专利授权的无细胞麦胚蛋白合成系统表达出来的重组蛋白,具有良好的可溶性,并有翻译后修饰、从而部分具有功能的蛋白。由此免疫原制备出的抗体对内源性蛋白的识别特异性更高。
Moreover, ISG20 demonstrated cell-type specific antiviral activity against yellow fever virus, a classical flavivirus. Overexpression of ISG20, however, did not inhibit propagation of severe acute respiratory syndrome coronavirus, a highly-pathogenic human coronavirus in Huh7.5 cells. The antiviral ...
- 《Molecular Cell》 被引量: 384发表: 2014年 Global correlation analysis for micro-RNA and mRNA expression profiles in human cell lines Microribonucleic acids (miRNAs) are small noncoding RNAs that negatively regulate gene expression at the posttranscriptional level. Although considerable p... Y ...
Dundr M., Misteli T. Functional architecture in the cell nucleus Biochem. J., 356 (2001), pp. 297-310 View in ScopusGoogle Scholar 2 Melese T., Xue Z. The nucleolus: an organelle formed by the act of building a ribosome Curr. Opin. Cell Biol., 7 (1995), pp. 319-324 View PDF...
Taken together, these results suggest that ISG20 expression might predict the immunosuppressive status of the TME and immune cell infiltration in gliomas, especially macrophage and T cell immune responses. In correlation analysis, we observed the most positive correlation between M2 macrophage infiltration...
Nevertheless, TOE1 may not be the only maturation exonuclease for U snRNAs in the cell. Here, we biochemically identify two exonucleolytic factors, Interferon-stimulated gene 20-kDa protein (ISG20) and the nuclear exosome as such candidates, using a newly developed in vitro system that ...
Nevertheless, TOE1 may not be the only maturation exonuclease for U snRNAs in the cell. Here, we biochemically identify two exonucleolytic factors, Interferon‐stimulated gene 20‐kDa protein (ISG20) and the nuclear exosome as such candidates, using a newly developed in vitro system that ...