ISG60 Negatively Regulates Cell Antiviral Responses by Disrupting the VISA-Associated Complexes 来自 学术范 喜欢 0 阅读量: 97 作者:LI,Chao,ZHANG,Weiping,LI,Ying,GUO,Lin,SHU,Hongbing 摘要: Viral infection activates the transcription factors NF-B and interferon regulatory factor 3 (IRF3), which ...
B Skaug,ZJ Chen 摘要: Cells express a plethora of interferon-stimulated genes (ISGs) in response to viral infection. Among these is ISG15, a ubiquitin-like protein (UBL) that can be covalently attached to both host and viral proteins. Here we review recent advances toward understanding the ...
ISG60 Negatively Regulates Cell Antiviral Responses by Disrupting the VISA-Associated Complexesinterferonantiviral responsenegative regulationViral infection activates the transcription factors NF-B and interferon regulatory factor 3 (IRF3), which collabo-rate to induce type I interferons (IFNs) and initiate...
B The cell viability, (C) sphere formation and (D) mRNA level of OCT4, NANOG and CD133 of 8505 C or KHM5M cells after ISGylation-WT/AA overexpression. E The cell viability of 8505 C or KHM5M cells after ISGylation-WT/AA overexpression combined with doxorubicin for 48 h. F The ...
Mol. Cell 44, 325–340 (2011). CAS PubMed PubMed Central Google Scholar Gane, E. J. et al. The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection. J. Hepatol. 63, 320–328 (2015). CAS PubMed Google Scholar Janssen, H. L. A. et...
B Skaug,ZJ Chen - 《Cell》 被引量: 286发表: 2010年 Mice Lacking the ISG15 E1 Enzyme UbE1L Demonstrate Increased Susceptibility to both Mouse-Adapted and Non-Mouse-Adapted Influenza B Virus Infection ISG15 functions as a critical antiviral molecule against influenza virus, with infection inducing...
TRIM21 Regulates Virus-Induced Cell Pyroptosis through Polyubiquitination of ISG12a Pyroptosis is a form of regulated cell death mediated by the gasdermin protein family. During virus infection, cell pyroptosis restricts viral replication... M Guo,W Cao,S Chen,... - 《Journal of Immunology》 被...
b Proliferation of control and ISG15CRISPR Panc185 and Panc354 cells, graphed as mean cell numbers ± sd determined at the indicated days post seeding (n = 3 biologically independent samples). c Representative flow cytometry plots for CD133 expression in control and ISG15CRISPR Panc185...
Localization studies using confocal fluorescence microscopy showed that EGFP-ISG20L2 was concentrated within the same nuclear domains as B23, a major nucleolar protein, and does not seem to accumulate in other cell compartments (Fig. 2A), notably Cajal bodies (Fig. 2B), contrary to ISG20 (40...
and by influenza B virus. ISG15 is secreted by cell lines of monocyte, T-lymphocyte, B-lymphocyte, human fibroblasts, and epithelial origins. Enhancement of NK cell proliferation, augmentation of non-major histocompatibility complex-restricted cytotoxicity, and induction of IFN-gamma from T cells id...