Frailty was measured using the trauma-specific frailty index (TSFI) and blood samples were collected within 24 hours of admission. Patients were stratified into two groups: frail (TSFI > 0.25) and nonfrail (TSFI ≤ 0.25). We then measured ...
InflammationImmune TolerancePregnancyPlacentationFemaleThe etiology of pre-eclampsia, a disorder specific to pregnancy, has not yet been clearly established. ... Dietl,J. - 《Journal of Perinatal Medicine》 被引量: 147发表: 2000年 Is Chronic Inflammation a Possible Cause of Obesity-Related Depression...
Leukocytosis (elevated WBC count) is a cardinal sign of acute inflammation, but simple elevation in WBC count is highly non-specific, and the rates of change and resolution in WBC and PLT associated with favorable acute inflammatory responses are not well-defined1,5. Patient responses appear to...
The immune system can sometimes mistake one's own organs and tissues for invaders, leading to inflammation throughout the body or in specific areas. This self-targeted inflammation is what causes the symptoms ofautoimmune diseasessuch as lupus and arthritis. Another cause ofchronic inflammationthat r...
NLRC4 is activated by NAIP proteins bound to specific ligands, NAIP 2 binds to the bacterial rod protein PrgJ whereas NAIP 5 and 6 bind to bacterial flagellin. Activation of the inflammasome leads to maturation and secretion of IL-1β and IL-18 aswell as inflammatory cell death by ...
Check access to the full text by signing in through your organization. Access throughyour organization Section snippets Pattern recognition receptors (PRRs) Vaccines induce specific acquired immune responses: the induction of antibody and cell-mediated immunity. Recent insight into immunological responses ha...
To determine whether the observed WAT-specific effects of semaglutide improve metabolic function of hepatocytes, we treated M1-iADIPO-iHEP-MPS with semaglutide (at 1 μM) in the circulating media for 48 h. We observed increased lipolysis in the iADIPO-MPS, as evidenced by reduced fluorescen...
2e–h). Taken together, TRIM47 expression is elevated by inflammatory stimulation and might play a role in the inflammatory response of endothelial cells. Since TNFα is the strongest stimuli in triggering and amplifying endothelial inflammatory response due to the TNF-specific membrane receptors, ...
The PCR products were detected in real-time and the results were analyzed with Quant StudioTM Design & Analysis Software v1.4.3 (Applied Biosystems) and calculated as 2−ΔCt where ΔCt is the difference between the threshold cycle (Ct) values of a specific gene and the endogenous control...
The structure of human ISG15 in complex with a N-terminal fragment of the NS1B protein showed the basis for this species specificity: the NS1B protein-binding site on ISG15 includes the two N-terminal residues of the linker region that are specific for human and non-human primate ISG15s...