Gene editing or specific inhibitors could be applied to our system to define the effects of adipokines such as adiponectin, leptin, resistin and omentin or metabolic and inflammatory pathways that impact hepatic insulin response in the setting of obesity and WAT inflammation2. Our findings of ...
They also showed that microglial MANF upregulation is not specific for ischemia as the ER stress inducer tunicamycin triggered MANF expression as well and caused microglial activation in primary cultures. Moreover, activated microglia/macrophages are highly migratory and MANF may be needed in the ...
We then identified the viral species associated with alcoholic beverages, coffee, and puffed food respectively, adjusting for disease (CD versus HC), geography and medications. A total of 83 viral species were associated with the consumption of alcoholic beverages, coffee, and puffed food, a majori...
Patients were excluded if they were under 18 yrs old, had a <2 day associated hospital stay, or underwent a laparoscopic procedure (for surgical cohorts). Some cohorts had additional inclusion/exclusion criteria specific to that setting: Amputation: Surgeries were included only if they involved ...
Finally, according to results of a study published in Nature, a specific subtype of bacteria known as Fusobacterium nucleatum, associated with periodontal disease, has been discovered to promote the growth of colorectal tumors. Findings from this study suggest that therapies targeting this bacteria ...
However, sympathetic nervous system activation is a general response to all stresses, and it stands to reason that there exist systemic coordinators of tolerance that are specific to particular environmental challenges. Our study demonstrates that GDF15 is a soluble factor that is induced and promotes...
First, the markers used are not very specific. There are many markers for evaluating M2 macrophages. Although we have investigated the polarization state of M2 macrophages from various perspectives. CD163 as a M2-polarized marker cannot cover all M2 macrophage subtypes. Second, the sample size ...
Large prospective studies have found that the pharmacological inhibition of pyroptosis is helpful in inhibiting or delaying AS (Table 1). Specific inhibitors targeting components of the complex signalling cascade of pyroptosis, such as inflammasome assembly, production of inflammatory cytokines, and GSDMD ...
et al. Microbiome influences prenatal and adult microglia in a sex-specific manner. Cell. 172(3), 500–16.e16 (2018). Article CAS PubMed PubMed Central Google Scholar Murtaj, V. et al. Age and sex influence the neuro-inflammatory response to a peripheral acute LPS challenge. Front. ...
1,3,4 Currently, there are no licensed vaccines or specific anti-CCHFV drugs, making the treatment options for CCHFV infection limited.5 Due to its great risk to public health and insufficient countermeasures, CCHFV has been continuously listed for years by WHO as a priority pathogen in ...