While the identities of many molecular inducers and cellular mechanisms have been established, response dynamics at the level of WBC and PLT effector populations are poorly understood. Leukocytosis (elevated WBC count) is a cardinal sign of acute inflammation, but simple elevation in WBC count is ...
Inflammation is a multicomponent response to tissue stress, injury and infection, and a crucial point of its control is at the level of gene transcription... Medzhitov,Ruslan - 《Nature Reviews Immunology》 被引量: 874发表: 2009年 Acute Inflammatory Response in Spinal Cord Following Impact Injury...
Abnormal inflammation/injury response (AIR) is commonly considered as a key common mechanism of both acquired and geneticHO(Kraftet al., 2016). For example,Thilaket al.(2015)reported that the increased level of C-reactive protein (CRP) anderythrocyte sedimentation rate(ESR), two clinical indicat...
1E,F, using the flow cytometry assay, PCA1 suppressed NO release in LPS-stimulated RAW264.7 cells in accordance with the results of the nitrite level and iNOS protein expression. Figure 1 PCA1 diminished LPS-stimulated inflammatory response in RAW264.7 cells. (A) Chemical structures of ...
Inflammation Cohort studies Educational level Social inequalities in health 1. Introduction Inflammation is an important and necessary component of the immune system broadly defined as the body’s protective reaction in response to infection or injury. A successful acute inflammatory response results in th...
Recently, electrochemical methods have received increased attention due to advantages such as fast response, low use of reagents, and high selectivity and sensitivity, making them suitable for custom-made sensors [12]. A fast search on the ScienceDirect platform by using “point-of-care detection”...
In conclusion, RJQM can effectively alleviate ASO and promote the recovery of lower limb blood flow by regulating the JAK2/STAT3 signaling pathway to reduce the inflammatory response. 1. Introduction Arteriosclerosis obliterans (ASO), a manifestation of atherosclerosis in the lower limbs, mainly ...
Deciphering the genetic architecture of variation in the immune response to mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A. 2012;109(4):1204–9. CAS PubMed PubMed Central Google Scholar Suhre K, Arnold M, Bhagwat AM, Cotton RJ, Engelke R, Raffler J, et al. Connecting ...
Collectively, we reveal a neutrophil-centered mechanism for modulating host inflammatory responses through control of the mode of neutrophil death and demonstrate its therapeutic potential. Neutrophil GSDME regulates the mode of cell death, which in turn dictates the host inflammatory response. GSDME ...
may contribute to a profibrotic environment by affecting the wound-repair process, level of oxidative stress, and the extent of remodeling. Studies support thatchemotactic factorsand neutrophils are present in IPF[20,51]and increase the likelihood ofdisease progressionand lack of response toimmunosuppres...