Garcia-Sanz R, Gonzalez-Fraile MI, Sierra M.The combination of thalidomide, cyclophosphamide and dexamethasone (ThaCyDex) is feasible and can be an option for relapsed/refractory multiple myeloma [J]. Hematol J,2002,3(1):43-48.Garcia-Sanz R,Gonzalez -Fraile MI,Sierra M.The combination of ...
PROteolysis TArgeting Chimeras (PROTACs) has become an appealing technology to utilize the event-driven MOA since its birth at 200110. A PROTAC is a heterobifunctional molecule composed of a protein of interest (POI) ligand, a linker and an E3 ubiquitin ligase recruiting ligand. It promotes the...
Thus, using antibiotics to deplete intestine bacteria, which have high β-glucuronidase activity, would be expected to have an antagonistic effect on PHY906’s biological activity. In addition, antibiotic treatment should also lead to reduced SN38 formation and damage of intestinal tissues. ...
Thalidomide caused devastating phocomelia in an estimated 20,000 to 30,000 infants before it was withdrawn. However, animal tests failed to reveal significant teratogenicity in 10 strains of rats; 11 breeds of rabbit; 2 breeds of dog; 3 strains of hamsters; 8 species of primates; and various...
Multiple myeloma (MM) is a plasma cell malignancy that responds to immunomodulatory thalidomide analogs (IMiDs) (Shortt et al., 2013a). Malignant plasma cells rely on the mutually permissive effects of IRF4 and cMYC (Delmore et al., 2011, Shaffer et al., 2008). The IMiDs bind cereblon ...
Extramedullary (e) relapse in multiple myeloma (MM) has an adverse prognosis, but knowledge concerning biological features and preferred treatment is scarc... L Rasche,C Bernard,MS Topp,... - 《Annals of Hematology》 被引量: 69发表: 2012年 Efficacy and safety of thalidomide in patients with...
Our observations, accordingly, showcase the therapeutic application of thalidomide in mending radiation-damaged cerebral vasculature.While antiretroviral therapy restrains the replication of HIV-1, its integration into the host genome establishes a persistent viral reservoir, effectively negating a complete ...
Other cats received aspirin at 5mg/pound given every two to three days in an attempt to decrease inflammation. All cats that received prednisolone or dexamethasone also received the antibiotic, ampicillin to fight infection. Several anabolic steroids were administered to encourage appetite and well-...
Binding of thalidomide to α1-acid glycoprotein may be involved in its inhibition of tumor necrosis factor a production Proc. Natl Acad. Sci. USA, 93 (1996), pp. 7552-7556 View in ScopusGoogle Scholar 52. A. Shevchenko, M. Wilm, O. Vorm, M. Mann Mass spectrometric sequencing of protei...
The thalidomide catastrophe around 1960 and additional experiences such as serious adverse drug reactions to high oestrogen oral contraceptives in the 1960s were probably the main reasons for the increasingly stringent requirements set to document development safety and the establishment of spontaneous report...