Clinical pharmacokinetics of thalidomide. Clin Pharmacokinet 2004;43:311-27.Clinical pharmacokinetics of thalidomide. Teo Steve K,Colburn Wayne A,Tracewell William G,Kook Karin A,Stirling David I,Jaworsky Markian S,Scheffler Michael A,Thomas Steve D,Laskin Oscar L. Clinical Pharmacology . 2004TEO,...
Background: Thalidomide has a chiral centre, and the racemate of (R)- and (S)-thalidomide was introduced as a sedative drug in the late 1950s. In 1961, it was withdrawn due to teratogenicity and neuropathy. There is now a growing clinical interest in thalidomide due to its unique anti-...
Background : Thalidomide has a chiral centre, and the racemate of ( R )- and ( S )-thalidomide was introduced as a sedative drug in the late 1950s. In 1961, it was withdrawn due to teratogenicity and neuropathy. There is now a growing clinical interest in thalidomide due to its unique...
Clinical pharmacology of thalidomide. Eur J Pharmacol 2001; 57: 365–76 Article CAS Google Scholar Teo S, Chandula R, Harden J, et al. Sensitive and rapid method for the determination of thalidomide in human plasma and semen using solid-phase extraction and liquid chromatography-tandem mass ...
Clinical pharmacology of thalidomide Background : Thalidomide has a chiral centre, and the racemate of ( R )- and ( S )-thalidomide was introduced as a sedative drug in the late 1950s. In 1961... T Eriksson,Sven Bjrkman,Peter Hglund - 《European Journal of Clinical Pharmacology》 被引...
Clinical pharmacologyis defined as the study of drugs in humans. Clinical pharmacologists work both to optimize the use of existing drugs and to develop new medicines. The modern era of clinical pharmacology arose in response to thethalidomidecrisis but mostadverse drug reactionscurrently are dose ...
pharmacologyofthalidomide,keyclinicalinvestigations, andstudiesthathaveraisedthepossibilityofnewthera- peuticuses.Wealsoconsiderthechallengesposedbythe drug’steratogenicityandotheradverseeffects. IMMUNOMODULATORYMECHANISMS OFACTION Thalidomide’seffects on immune function are incom- ...
In subject area: Pharmacology, Toxicology and Pharmaceutical Science Clinical research is the study of health and disease in human subjects (or materials of human origin, such as tissues, specimens, and cognitive phenomena) that directly impacts the patient’s health outcome. ...
including their event-driven (rather than occupancy-driven) pharmacology, which permits sub-stoichiometric drug concentrations for activity, their capacity to act iteratively and target multiple copies of a protein of interest, and their potential to target nonenzymatic proteins that were previously conside...
Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders. Chem Soc Rev. 2022;51(19):8216–57. Article CAS PubMed PubMed Central Google Scholar Ito T, Handa H. Molecular mechanisms of thalidomide and its derivatives. ...