Impaired muscle mitochondrial oxidative capacity is associated with future cognitive impairment, and higher levels of PET and blood biomarkers of Alzheimer’s disease and neurodegeneration. Here, we examine its associations with up to over a decade-long
State the difference between the two ways in which ATP is synthesized in the cell (substrate-level phosphorylation, and oxidative phosphorylation). Which of the following accurately describe the difference(s) between oxidative phosphorylation and substrate-level phosphorylation during ...
Also decreased were LXR/RXR signaling, lipid degradation, oxidative phosphorylation, fatty acid oxidation, and multiple xenobiotic metabolisms. A decrease in fatty acid oxidation by OPA1 LKO might be manifested in an increase of RER (Fig. 1). These predicted decreases suggest general attenuation of...
The majority of H2O2 detected during hypoxia by HSP-FRET appears to originate from complex III of the ETC, since it is attenuated by stigmatellin (Figure 1D), which inhibits electron flux into complex III at the same site as myxothiazol. Myxothiazol and stigmatellin inhibit hypoxic stabilization...
Wild-type p53 promotes cancer metabolic switch by inducing PUMA-dependent suppression of oxidative phosphorylation. Cancer Cell. 2019;35(2):191–203e8. Imbs TI, Ermakova SP, Malyarenko Vishchuk OS, Isakov VV, Zvyagintseva TN. Structural elucidation of polysaccharide fractions from the brown alga...
Fig. 1. Oxidative phosphorylation system (OXPHOS). ADP, adenosine diphosphate; ATP, adenosine triphosphate; Cyt c, cytochrome c; CI-IV, respiratory complexes I-IV; CV, ATP synthase; ETC, electron transport chain; e−, electrons; FADH2/FAD, reduced and oxidized flavin adenine dinucleotide; H2O...
Released arginine deiminase was able to significantly reduce the growth of HT-29 and HCT116 cells due to the depletion of arginine, which led to decreased levels of c-Myc, reduced phosphorylation of p70-S6 kinase, and cell cycle arrest. The ADI release and cytostatic properties were strain-...
It has been established that in Fumarate Hydratase (FH)-deficient kidney cancer, there is impaired oxidative phosphorylation with metabolic shift to aerobic glycolysis to generate ATP required for the increased energy demand of the rapidly proliferating tumor cells [33]. This process requires the ...
NAD+ mediated mitochondrial quality control is the core mechanism of preventing heart aging, involving mitochondrial dynamics, permeability, biological synthesis, and mitophagy. As a coenzyme, NAD+ also further stabilizes mitochondrial oxidative phosphorylation. ...
In this study, we discovered that normal chondrocyte hypertrophy is marked by a bioenergetic shift in the equilibrium of glycolysis and oxidative phosphorylation, which is further balanced by the PPP. This equilibrium is critical for proper chondrocyte maturation and is regulated by IGF2 in a stage...