When is iron overload deleterious, and when and how should iron chelation therapy be administered in myelodysplastic syndromes? Best Pract. Res. Clin. Haematol. 2013; 26: 431-444.Steensma DP, Gattermann N. When is iron overload deleterious, and when and how should iron chelation therapy be ...
However, there has been safety concern of SPIONs with cirrhosis related to excess iron-induced oxidative stress. In this study, the impact of iron overload by SPIONs was assessed on a mouse cirrhosis model. A single dose of SPION injection at 0.5 or 5鈥塵g Fe/kg in the cirrhosis group...
Therefore, we investigated the effects of iron overload on the aorta of rats. A rat model of iron overload was established by intraperitoneal injection of Iron-Dextran. The levels of iron, calcium, and ALP activity were detected. Von Kossa staining and Perl's staining were conducted. The ...
Iron-overload cardiomyopathy is a prevalent cause of heart failure on a world-wide basis and is a major cause of mortality and morbidity in patients with secondary iron-overload and genetic hemochromatosis. We investigated the therapeutic effects of resv
In iron overload diseases (thalassemia, sickle cell, and myelodysplastic syndrome), iron is deposited in all internal organs, leading to functional abnormalities. Hematopoietic stem cell transplantation (HSCT) is the only treatment offering a potential cure in these diseases. Our aim was to describe...
A complementary strategy that may help lower ferritin levels in people with hemochromatosis is following adiet lower in ironbut high enough in nutritious foods. Fiber, green tea, and coffee might also lower iron absorption in people with iron overload. ...
Nearly all forms of hereditary hemochromatosis are characterized by pathological iron accumulation in the liver, pancreas, and heart. These tissues preferentially load iron because they take up non-transferrin-bound iron (NTBI), which appears in the plasma during iron overload. Yet, how tissues take...
Moderately high serum ferritin concentration is not a sign of iron overload in dialysis patients (letter) 来自 国家科技图书文献中心 喜欢 0 阅读量: 8 作者:K Zadeh-K,FC Luft,MH Humphreys 关键词:Ferritin Hemodialysis Iron Overload Kidney Failure Chronic 铁蛋白 血液透析 铁超负荷 肾功能衰竭 慢性 ...
Automated RBC RBC exchange compared to manual exchange transfusion for children with sickle cell disease is cost‐effective and reduces iron overload 来自 国家科技图书文献中心 喜欢 0 阅读量: 21 作者:Dedeken,Laurence,Lê,Phu,Quoc,Rozen,Laurence,El,Kenz,Hanane ...
Wilson’s disease (WD) is a rare hereditary disorder of copper metabolism. Some data suggest that iron metabolism is disturbed in WD and this may affe