Our studies offer the first direct evidence linking HER2 to a systemic inflammatory mechanism that orchestrates HER2-mediated tumor growth. We suggest that the HER2–IL-6–STAT3 signaling axis we have defined in breast cancer could prompt new therapeutic or prevention strategies for treatment of HER2...
To confirm the anti-inflammatory effects of DEOPA, BV2 cells (a microglia cell line) were treated with LPS (200 ng/ml) for 24 hrs and nitrite levels were measured in the presence or absence of DEOPA. NO production was dose-dependently suppressed by co-treating DEOPA (1, 5, or 1...
IL-6, Trp53, and the high mobility group (Hmg) protein family, which is involved in ageing and neurodegeneration via pro-inflammatory activity [44,45], were downregulated in theA. muciniphila-treated group (Fig.4c–e). To confirm the results, plasma cytokine and chemokine levels were compar...
new antimicrobials; targeted anti-inflammatory and immunoregulatory agents; novel signalling molecules that affect gut pain, sensation, secretion and motility; and agents that enhance vaccination efficacy or modulate immune responses or that exert beneficial metabolic effects via interactions with dietary compo...
The anti-inflammatory activity of curcumin and the synthetic analogs was tested in RAW264.7 cells stably expressing luciferase downstream of an NF-κB response element. The dose-dependent inhibition of LPS-induced luciferase activity by the analogs was expressed as IC50 values (Fig. 1A). Compounds ...
HCMV infection also induces monocyte chemoattractant protein-1 (MCp-1), MCp-2, and macrophage colony-stimulating factor[31], and stimulates macrophages to produce and release interleukins such as IL-1, IL-6, IL-8, and IL-10, as well as inflammatory factors such as TNF-α. These ...
Additional data generated using mice treated with recombinant IL-22 alone or in combination with anti-IL-18 antibody suggest that full protection of gut barrier integrity requires both IL-18 inhibition and IL-22 restoration following ethanol and burn injury. Together our findings suggest that AHR ...
or chronic inflammatory conditions [13]. IL-6 is known to be involved in various liver pathologies, especially liver regeneration and cancer [14]. IL-6 induced compensatory proliferation of hepatocytes in a diethylnitrosamine (DEN)-induced hepatocarcinogenesis model, and either deletion of IL-6 or...
A critical target of IL-23 is a unique subset of tissue-homing memory T cells, which are specifically activated by IL-23 to produce the proinflammatory mediators IL-17 and IL-6. This pathway may be responsible for chronic intestinal inflammation as well as other chronic autoimmune inflammatory ...
let-7 biogenesis in a genetic model of depression YB Wei1,2, JJ Liu1,2, JC Villaescusa2,3, E Åberg4, S Brené4, G Wegener5,6, AA Mathé7 and C Lavebratt1,2 Elevation of the proinflammatory cytokine IL-6 has been implicated in depression; however, the mechanisms remain elusive. ...