Both mouse and human in vivo models of HER2-amplified breast carcinoma relied critically on this HER2–IL-6–Stat3 signaling pathway. Our studies offer the first direct evidence linking HER2 to a systemic inflammatory mechanism that orchestrates HER2-mediated tumor growth. We suggest that the HER2...
Since EP is known to have strong anti-inflammatory effects, we examined anti-inflammatory potency of DEOPA in the postischemic brain. DEOPA (5 mg/kg, i.v.) was administered at 6 hrs post-MCAO and brain sections obtained at 2 days post-MCAO were stained with antibody against Iba-...
Mast cells, eosinophils, inflammatory cytokines and immunoglobulin (Ig)E accumulate in asthmatic lungs and in the injured heart and vasculature of patients with CVD. Clinical studies show that many anti-asthmatic therapies affect the risk of CVD. As such, allergic asthma and CVD may share common...
This study reveals thatA. muciniphila, which is mediated in the gut microbiota by metformin, modulates inflammation-related pathways in the host and improves cognitive function in aged mice by reducing the pro-inflammatory cytokine IL-6. Video Abstract Graphical Abstract Background Metformin is a f...
In this paper we asked whether the increased production of two proinflammatory cytokines – tumor necrosis factor-α (TNFα) and interleukin-6 (IL6) in the absence of the inflammatory stimulus, a phenomenon frequently occurring in the elderly, may contribute to the decrease of natural killer (...
B, effect of isolated spiroepoxide and bicyclopentadione metabolites, vanillin, and ferulic acid on NF-κB activity. The anti-inflammatory activity of curcumin and the synthetic analogs was tested in RAW264.7 cells stably expressing luciferase downstream of an NF-κB response element. The dose-...
Moreover, expression of the chemokine receptor Ccr2 and proinflammatory cytokines Il1b and Tnfa in the DRG were significantly reduced to levels similar to those of sham-operated animals. Conclusions This study provides the first evidence in an OA animal model that EGCG significantly slows OA ...
that inflammation and proinflammatory cytokines are important for the tumor process12 and in this report, we explore the effects of hyperactivated Notch signaling in breast cancer, with a particular focus on non-canonical Notch signaling, and the proinflammatory cytokine interleukin-6 (IL-6). IL...
Number of organ failures and arterial IL-6 concentrations at presentation were associated with increased mortality. The portal circulation has a distinct immunological milieu characterised by a pathological neutrophil phenotype and an anti-inflammatory cytokine profile associated with heightened LPS levels. ...
These different cell types may contribute to the secretion of the pro-inflammatory cytokines tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-1), interleukin 6 (IL-6), chemokine ligand 5 (CCL5), and anti-inflammatory cytokine interleukin 10 (IL-10), as well as hormones such as ...