The in vivo regulation by metal ions of the enzymes of heme metabolism in kidney-particularly of ALAS, the rate-limiting enzyme in heine formation- was investigated. Ni(2+) and Pt(4+), metals which do not enzymatically form metalloporphyrins, were found to regulate ALAS in kidney as they ...
Heme degradation enzyme biliverdin IXβ reductase is required for stem cell glutamine metabolism.Bioenergetic requirements of hematopoietic stem cedoi:10.1042/bcj20180016Zongdong LiNatasha M. NesbittLisa E. MaloneDimitri V. GnatenkoSong WuDaifeng Wang...
Western blot analysis revealed that the expression of the cytoprotective enzyme, heme oxygenase-1 (HO-1), was induced and coincident with the anti-inflammatory action of 15d-PGJ2. Inhibition of HO-1 activity or scavenging carbon monoxide (CO), a byproduct derived from heme degradation, ...
1 This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). ll OPEN ACCESS Article of hemoglobin releases free heme, which is partly detoxified by crystallization into hemozoin (Hempelmann, 2007)...
Heme-oxygenase 1 (HO-1) is an inducible enzyme which catabolizes heme, through an enzymatic reaction which produces biliverdin (subsequently converted to bili- rubin), carbon monoxide and iron15. The ability to induce HO-1 within renal tissue appears a critical event for nephroprotection16,17 ...
Since the characterization of cytochrome c 552 as a multiheme nitrite reductase, research on this enzyme has gained major interest. Today, it is known as ... PMH Kroneck - 《Journal of Biological Inorganic Chemistry Jbic A Publication of the Society of Biological Inorganic Chemistry》 被引量: ...
Here,α-Amy2/54gene expression was used as a molecular probe to investigate the interrelationship among nitric oxide (NO), cyclic GMP (cGMP), and heme oxygenase-1 (HO-1) in GA-treated wheat aleurone layers. The inducible expressions ofα-Amy2/54andα-amylase activity were respectively amplif...
there is an additional step in the pathway downstream of bilirubin reduction performed by the gut microbiome where the enzyme is still unknown: the reduction of urobilinogen to stercobilinogen. Similar to bilirubin, urobilinogen may serve as a terminal electron acceptor for microorganisms encoding ...
Shekhawat GS, Verma K (2010) Haem oxygenase (HO): an overlooked enzyme of plant metabolism and defence. J Exp Bot 61:2255–2270 Article PubMed CAS Google Scholar Shekhawat GS, Dixit S, Verma K, Nasybullina EI, Kosmachevskaya OV, Topunov AF (2011) Heme oxygenase: enzyme with func...
In human umbilical vein endothelial cell (HUVEC), SHAH ameliorated H2O2-mediated HUVEC injury through the restoration of antioxidant enzyme activities and glutathione. In addition, SHAH inhibited HUVEC apoptosis through the down-regulation of caspase-3 and p53 and the increase bcl-2/bax ratio. These...