Interestingly, a U-shaped association between Hb and CVD incidence or outcome has been observed, meaning both anemia and high Hb levels are implicated [51, 52]. As we did not have anemic individuals in the current study population (3% individuals had Hb < 130 g/L and only 2 ...
While iron is often a limiting nutrient to Biology, when the element is found in the form of heme cofactors (iron protoporphyrin IX), living systems have excelled at modifying and tailoring the chemistry of the metal. In the context of proteins and enzymes, heme cofactors are increasingly foun...
In these cases, the exact nature of the coordination sphere and the oxidation state of the metal is of utmost importance. Unfortunately, the redox-active nature of metal cofactors makes them especially susceptible to photoreduction, meaning that information obtained by photoreducing X-ray sources ...
and coenzymes. These compounds are more soluble in water, meaning they can spread into groundwater, which are hazardous to the health of humans and other organisms1,2. A pyridine ring opening reaction step is a common feature of most chemical and enzyme-based degradation processes for such pol...
Multi-hemeproteins:Nature'selectronicmulti-purposetool KathrynD.Bewley,KatieE.Ellis a ,MackenzieA.Firer-Sherwood a ,andSeanJ.Elliott * DepartmentofChemistry,BostonUniversity,Boston,MA02215 Abstract WhileironisoftenalimitingnutrienttoBiology,whentheelementisfoundintheformofheme cofactors(ironprotoporphyrinIX)...
Interestingly, a U-shaped association between Hb and CVD incidence or outcome has been observed, meaning both anemia and high Hb levels are implicated [51, 52]. As we did not have anemic individuals in the current study population (3% individuals had Hb < 130 g/L and only 2 ...
The clock genes in cultured cells are not synchronized because the culture conditions, such as temperature and CO2/O2 levels, remain constant, meaning factors that typically reset the circadian rhythm do not change throughout the day. Therefore, we synchronized the clock genes of these cells using...
The actual meaning of this differential expression pattern of autophagic proteins remains unclear and warrants further investigation. Nevertheless, the role of Schwann cells in the initial response to injury is becoming progressively clearer, whereas the function of repair Schwann cells during the late ...