NAC is used medically as an antidote to acetaminophen poisoning because it restores levels of glutathione in the liver which is rapidly depleted as the liver tries to breakdown acetaminophen into its metabolite N-acetyl-benzoquinone imine (NAPQI). Detoxification of NAPQI requires high concentrations of...
Now, does it mean that amyloid formation is driven by a specific primary sequence or is it more generally an inherent property of polypeptides under a given biochemical environment? In this context, an interesting observation was reported by Guijarro et al., wherein they found PI3-SH3 small gl...