The current prognostic indica- tors for evaluating lung cancer include epidermal growth factor receptor (EGFR), K-ras gene mutation, TTF-1, Napsin A34–36; however, these indicators certain limitations in specificity and sensitivity. ERRα may be able to perform an auxiliary assessment in cases ...
Moreover, the high molecular heterogeneity of GBM tumors, exemplified by unevenly distributed amplifications of EGFR and PDGFR, challenges the effectiveness of receptor tyrosine kinase inhibitors. Analysis of The Cancer Genome Atlas (TCGA) and single-cell RNA-seq further reveals substantial heterogeneity...
Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma. Br J Cancer. 2003; 89 :1266–1269. doi: 10.1038/sj.bjc.6601241. [ Cross Ref ]Kallio JP, Hirvikoski P, Helin H, Kellokumpu-Lehtinen P, Luukkaala T, Tammela TLJ, Martikainen PM. ...
Overall survival is the “gold standard” endpoint in cancer clinical trials. It plays a key role in determining the clinical- and cost-effectiveness of a new intervention and whether it is recommended for use in standard of care. The assessment of overa
In breast cancer theCXCR4mRNA promotes metastasis not only through its protein, the CXCR4 chemokine receptor, but also through theCXCR43′UTR that sponges the tumor-suppressive miR-146a, thus leading to the upregulation of TRAF6 and EGFR, two oncoproteins that activate the NF-κB pathway.148 ...
One-way ANOVA followed by post hoc Tukey test was applied to examine the mean eGFR across BMI categories among the insulin sensitive individuals, and also between insulin sensitive and insulin resistant obese individuals. We also examined the difference in mean eGFR across tertiles of IS and 2-...
Dong QZ, Wang Y, Tang ZP, Fu L, Li QC, Wang ED, Wang EH: Derlin-1 is overexpressed in non-small cell lung cancer and promotes cancer cell invasion via EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9. Am J Pathol 2013, 182:954–964. 34. Katayama A, Bandoh N, Kishibe K,...
(A) AURKA phosphorylates RPS6KB1 is mutant K-Ras expressing cells. AURKA colocalizes and directly phosphorylates RPS6KB1 at T389 in K-Ras mutant gastrointestinal cancer cells leading to increased proliferation and survival. (B) AURKA activates EGFR signaling via SDCBP. AURKA stabilizes SDCBP by...
Of note, receptor tyrosine kinase (RTK) signaling, including signaling via EGFR, was also upregulated in response to UHRF1 loss. We next inferred activity of known cancer-related pathways from gene expression data using PROGENy38. In both cell lines, UHRF1 knock-down lead to an increase in...
Recently, an eGFR for Japa- nese patients was proposed by the Japanese Society of Neph- rology (18); however, its clinical usefulness has not yet been fully established. In this study, we investigated for the first time the significance of eGFR as an index and predictor of arterial ...