Unfortunately, despite good initial response, patients who was treated with third generation EGFR TKI would develop acquired resistance and several mechanisms had been identified and the commonest being C797S mutation at exon 20. Several novel treatment options were being developed for patients who had...
1F). Since we did not observe any proliferation under control conditions or after 4 h (Fig. 1E) the gap closure of WT cells cannot be attributed to proliferation but results from collective cell migration. These data are in good agreement with the known role of EGF in collective migration ...
AREG has been suggested as a good target for treating cancer, inhibition of AREG by siRNA or monoclonal antibodies results in apoptosis of cancer cells or shrinkage of mice xenograft tumors.15,61,83 Our study showed that transfection of SKOV-I6 cells with miR-34c-5p resulted in significant ...
Compound E was tested as a tubulin inhibitor and compared with colchicine and displayed a good result. Molecular docking of the highest active compound, compound E, correlated with the experimental results and elucidated the mode of binding of these derivatives with the EGFR and tubulin binding ...
It was clear that derivatives with fluoro, chloro, bromo, trifluoromethyl, or nitro groups were more potent than others with unsubstituted or methyl groups. Compound St.44 is regarded as a good option for future investigation and refinement as EGFR kinase inhibitors with improved anticancer efficacy...