The volume of epicardial adipose tissue (EATV) is increased in type-2 diabetes (T2D), while its attenuation (EATA) appears to be decreased. Similar patterns have been suggested in pre-diabetes, but data is scarce. In both pre-diabetes and T2D, any independent role of EATV and EATA in ...
Revisiting Screening for Type 2 Diabetes Mellitus: To Screen or Not to Screen, That Is the Question/In reply/In reply To explore a possible association between serum concentration of leptin, insulin sensitivity and non-insulin-dependent diabetes mellitus (NIDDM). Forty fir... Saleh A Aldasouqi...
Regulation of obesity-related insulin resistance with gut anti-inflammatory agents. Cell Metab. 2015;21(4):527–42. Article CAS PubMed Google Scholar Brun P, Castagliuolo I, Di Leo V, et al. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic ...
Eukaryotic elongation factor 2 kinase (eEF2K), a calcium/calmodulin-dependent kinase, is also known to be activated by NMDA receptors leading to protein synthesis inhibition. Here we explored how does eEF2K participate in NMDA-induced NO signaling. We found that when this enzyme is inhibited, ...
Progressive decline of β-cell function in non-insulin dependent diabetes Raised proinsulin levels may be one marker of β-cell failure. Maturity-onset diabetes of the young results from mutations in genes coding for islet proteins causing persistent β-cell dysfunction. Identification of a single ca...
Moreover, recent studies suggest that metformin can also attenuate anxiety-like behaviors linked to several nonanxious models, such as the cerebral ischemia model, insulin-resistant model, and nicotine withdrawal model [16,17,18]. Nevertheless, the specific cellular and neural circuit mechanisms ...
DM Skovronsky, RW Doms, VM Lee Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture J Cell Biol, 141 (1998), pp. 1031-1039 View in ScopusGoogle Scholar 19 DH Chui, H Tanahashi, K Ozawa, S Ikeda, F Checler, O Ueda, H Suzuk...
Mice Deficient in the Insulin-regulated Membrane Aminopeptidase Show Substantial Decreases in Glucose Transporter GLUT4 Levels but Maintain Normal Glucose ... The -regulated () is a -dependent . It is the homologue of the . In fat and muscle , colocalizes with the -responsive in and redistribu...
Caspase-dependent and -independent death pathways in cancer therapy. Apoptosis. 2000;5:17–20. Article CAS Google Scholar Kim IY, Kwon M, Choi MK, Lee D, Lee DM, Seo MJ, et al. Ophiobolin A kills human glioblastoma cells by inducing endoplasmic reticulum stress via disruption of thiol ...
2). Similarly, Cox proportional hazard model identified MET treatment to be associated with improved outcome. No such relationship was observed for therapy with insulin, SU derivatives or DPPIV-inhibitors (Table 3 in the Online Supplement). Figure 2 Event-free survival DM patients according DM ...