established that insulin glargine is a cost-effective alternative to NPH insulin [insulin suspension isophane] in patients with type 2 DM in that country,1while investigators from Spain and the US reached the same conclusion regarding these treatments among type 2 diabetic patients in Spain.2L...
Early, aggressive use of insulin therapy may improve β-cell function, wrhich in turn could delay, halt, or even possibly reverse the natural progression of type 2 DM. With a more aggressive approach to starting and intensifying insulin therapy, patients may be more likely to achieve and ...
A non‐steady state dose‐response study was designed to quantitate peripheral sensitivity to insulin and pancreatic responsiveness to glucose, and to assess their relative contribution to glucose intolerance in Type 2 diabetes (Type 2 DM, non‐insulin‐dependent). Eleven lean and eleven obese patient...
obesity leads to insulin resistance——a condition in which the body’s cells find it hard to respond properly to the hormone insulin, and this is the core of type 2 diabetes. This paper points out the current epidemiological characteristics of adolescent T2DM, aiming to provide a reference for...
外文名:Insulin ,RI, Insulyl,Insulin, Crystalline Insulin, Regular Insulin药理作用: 促进血循环中葡萄糖进入肝细胞、肌细胞、脂肪细胞及其他组织细胞合成糖原使血糖降低,促进脂肪及蛋白质的合成。 适应症: 主要用于糖尿病,特别是胰岛素依赖型糖尿病: 1.重型、消瘦、营养不良者; 2.轻、中型经饮食和口服降血糖药...
The close relationship between type 2 DM and CVD has led to the common soil hypothesis, postulating that both conditions share common genetic and environmental factors influencing this association. However, although the common risk factors of both CVD and type 2 DM, such as obesity, insulin ...
Type 2 diabetes mellitus (T2DM) is a persistent state of hyperglycemia and glucose intolerance that occurs when the body cannot respond fully to insulin, followed by an increase in insulin production and a subsequent insulin deficiency. Once mainly limited to older adults in the twentieth century,...
Summary Aims Type 2 diabetes mellitus (DM) develops when insulin resistance overcomes the capacity of compensatory insulin secretion. Insulin resistance m... P Bjrntorp,G Holm,R Rosmond - 《Diabet Med》 被引量: 802发表: 1999年 Disruption of Insulin Receptor Substrate 2 Causes Type 2 Diabetes ...
As in the adult population, type 2 DM in children and youth occurs as a result of insulin resistance coupled with relative beta-cell failure. While there appears to be a host of potential genetic and environmental risk factors for these aberrations, perhaps the most significant risk factor is ...
Type 2 immunity also plays roles in glucose homeostasis [158], thermogenesis [159], and insulin resistance [160]. Mounting evidence suggests, moreover, that type 2 immune responses in the brain and brain borders could shape adaptive and dysfunctional neurological processes. Type 2 cytokines are ...