Clozapine is a neuroleptic agent whose structure consists of a dibenzodiazepine derivative with a piperazinyl side chain. It has been classified as an atypical neuroleptic drug due to its unique neuropharmacologic profile. Clozapine has a weak binding affinity for dopamine D-1 and D-2 receptors by...
The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man. Clozapine, a dibenzodiazepine antipsychotic, is associated with a 0.8% incidence of agranulocytosis. This clinically restrictive toxicity has been attribut... JL Maggs,D Williams,M Pir...
Clozapine( atypical) has a 4:1 D2/D3 receptor affinity ratio. Clozapine binds D4 about 10-fold better than D2. Clozapine has high affinity for 5-HT2,α1 and histamine H1 receptors. 吩噻嗪药理作用Phemothiazines CNS effect①The antipsychotic effects are believed to be due to antagonism ...
SynopsisDouble Blind comparative trial of a new dibenzodiazepine derivative Clozapine (Leponex) with Chlorpromazine was conducted in the treatment of acute... Edmond,Chiu,Graham,... - 《Australian & New Zealand Journal of Psychiatry》 被引量: 7发表: 2016年 Indicators of response to clozapine trea...
postmarketing drug surveillanceClozapine (Clozaril), a tricyclic dibenzodiazepine, causes fewer extrapyramidal side effects than do other antipsychotic drugs. ... AM Walker,LL Lanza,F Arellano,... - 《Epidemiology》 被引量: 691发表: 1997年 Aripiprazole: a new atypical antipsychotic with a differen...
et al. Childhood-onset schizophrenia: a double-blind, randomized clozapine-olanzapine comparison. Arch. Gen. Psychiatry 63, 721–730 (2006). 21. Polanczyk, G. et al. Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort. Arch. Gen. Psychiatry 67, 328...
Another patient took daily doses of clozapine — an antipsychotic so powerful that the FDA required five “black box warnings” and a regular blood-testing regimen because of its dangerous tendency to lower white blood cell counts. With the CBD capsules, he found he could halv...
Clozapine is a dibenzodiazepine neuroleptic with atypical pharmacological and clinical profiles. Treatment with this drug may be complicated with agranulocytosis (AGR). It is likely that defective oxidative mechanism may be the cause of AGR. A candidate gene, dihydronicotinamide riboside (NRH) quinone...
Clozapine is an effective antipsychotic for the treatment of antipsychotic-resistant schizophrenia; however, specific types of A/B adverse effects and clozapine-discontinuation syndromes are also well known. To date, both the critical mechanisms of clinical actions (effective for antipsychotic-resistant sch...