Clozapine is used to treat certain mental/mood disorders (schizophrenia, schizoaffective disorders). Clozapine may also help prevent suicide in people who are likely to try to harm themselves. Clozapine belongs to a class of drugs known as atypical antipsychotics. ...
Clozapine is the prototype of a new class of drugs, referred to as 'atypical antipsychotics'. As a matter of fact, the antipsychotic activity of the drug was not predicted by the first studies with quantitative electroencephalography (QEEG), which actually reported an antidepressant pattern. All...
Discontinuation of CYP1A2 or CYP3A4 Inducers: Consider reducing clozapine orally disintegrating tablets dose when CYP1A2 (e.g., tobacco smoke) or CYP3A4 inducers (e.g., carbamazepine) are discontinued (2.7, 7.1). Anticholinergic drugs: Concomitant use may increase the risk for anticholinergic ...
High blood sugaror diabetes,high cholesterol, and weight gain have happened with drugs like this one. These may raise the chance of heart and brain blood vessel disease. If you have high blood sugar (diabetes), you will need to watch your blood sugar closely. Tell your doctor if you get...
It?may have a synergistic effect with the sedating action of other drugs such as benzodiazepines, and thus respiratory depression may result with concomitant use. Care should be taken, especially if the latter drugs are given parenterally. View all 4.3 Toxicity LD50 in mice, rats (mg/kg):...
Figure 1 the synthesis route of clozapine Precautions 1. Induction of the decrease of neutropenia or its development into agranulocytosis is the most serious side effects of this product. So do not take drugs which causes leukopenia simultaneously while taking clozapine, especially avoid taking the...
Switching to one of the less toxic drugs such as olanzepine may provide benefit, but once a patient has developed clozapine-induced neutropenia or agranaulocytosis, the risk of a repeat toxic event using a drug such as olanzapine appears to be significantly increased. View chapter...
Potential For Other Drugs To Affect VERSACLOZ Clozapine is a substrate for many cytochrome P450 isozymes, in particular CYP1A2, CYP3A4, and CYP2D6. Use caution when administering VERSACLOZ concomitantly with drugs that are inducers or inhibitors of these enzymes. ...
Allon Therapeutics Inc., a clinical-stage biopharmaceutical company, engages in the development of drugs to treat neurodegenerative diseases. Its lead product, Davunetide intranasal, an intranasal drug product, which is in Phase IIa clinical trial for the treatment for Alzheimer's disease, schizophren...
Clozapine is known to treat both positive and negative symptons, and unlike many other psychoactive drugs, can actually increase a patient's clarity of thought and perception of reality. There are other uses for this drug, but they are considered "off-label" or in the experimental or testing ...