Classification of familial forms of thoracic aortic aneurysm should allow a better understanding of these diseases and therefore standardization of initial evaluation of the patients (vascular evaluation limited or not to the aorta, and extravascular evaluation, including or not skeleton, eyes, neurology,...
The perceived inefficiency of pharmaceutical drug development has been widely discussed [1–5]. Only 20 to 30 new chemical entities (NCEs: drugs not containing a previously approved active ingredient) are approved per year in the US [4], and each successful NCE requires an average of US$1.78 ...
Drug-induced cognitive impairment (DICI) is a well-established, yet under-recognised, complication of many types of pharmacological treatment. While there
‘ideal trip terminator/modulator’, possibly due to its related activity on GABA-A receptors, hence the associated sedation and rewarding glutamatergic stimulation of the ventral tegmental area DAergic neurons [42]. Finally, although difficult to be interpreted, misuse/abuse cases ofclozapineingestion...
In addition to these four broad categories, there a number of other drugs that affect the mind. These compounds are used to treat a variety psychological and neurological disorders and include antidepressants; antipsychotic medication, such as clozapine, chlorpromanzine, and haloperidol; and drugs for...
The doses of risperidone (0.3–1 mg/kg) and clozapine (3 mg/kg) selected are equivalent to the doses used clinically at the commencement of antipsychotic drug treatment, with human dose equivalents of 1.5–5 mg of risperidone and 15 mg of clozapine (Food and Drug Administration, 2005). ...
Refs: /Schizophrenia.pdf Film: One Flew Over the Cuckoo’s Nest (1975) * Classification of antipsychotics Typical: Phenothiazines (吩噻嗪类): chlorpromazine, etc Thioxanthenes (硫杂蒽类): chlorprothixene, etc Butyrophenones (丁酰苯类): haloperidol, etc Atypical: Clozapine, olanzapine, ...
Home / AHFS Classification – Drug Assignments The following tables describe changes to the AHFS Pharmacologic-Therapeutic Classification© that will be published in the 2021 edition of AHFS Drug Information® (February 1, 2021), as well as any new classes added after the publication of the ...
Table 1 Overall characteristics of reports of myocarditis in the WHO pharmacovigilance database, VigiBase®. Full size table Drugs associated with myocarditis The most represented drugs were clozapine (3035/5108, 59.4%), immune checkpoint inhibitors (522/5108; 10.2%), mesalazine (311/5108, 6.1%)...
“Omics” approaches can be used for identification or classification of toxic compounds or to generate mechanistic understanding of cellular processes underlying adverse outcomes to those compounds. Therefore, “omics” technologies are very suited to enhance preclinical safety assessment of DILI [200]. ...