In spite of treatment with full doses of several of these drugs the patient failed to respond. He was therefore put on the first of the so-called “atypical” neuroleptics, clozapine. These atypical drugs have a much lower affinity for D2 receptors, and often have a wide range of other ...
We also discuss the possible role of the H2R antagonism of clozapine for neutropenia/agranulocytosis induced by this compound. Finally, we discuss the methodological, conceptual, and clinical limitations of our study.Heidrun ApplDepartment of Pharmacology and ToxicologyTobias Holzammer...
The 'atypical' antipsychotics, risperidone (0.18), ziprasidone (0.38), aripiprazole (1.6), olanzapine (0.99), and clozapine (11.1) were less potent for occupying D2-like receptors. New compounds, displaying marked agonism at 5-HT1A receptors in addition to D2 receptor affinity, exhibited varying...
In contrast, clozapine increased DA in mPFC of EEDQ-treated rats whose 5-HT1ARs were protected (50% of control rats). These results indicate that (1) 5-HT1ARs are necessary for the APDs-induced elevation in cortical DA transmission, and (2) this effect does not require 5-HT2AR blockade...
The serotonin 5-HT7 receptor has been linked to various psychiatric disorders, including schizophrenia, anxiety and depression, and is antagonized by antipsychotics such as risperidone, clozapine and lurasidone. In this study, we examined whether inhibiting the 5-HT7 receptor could reverse behavioral ...