深入了解：揭示生物化学中的神秘力量——激酶 (Kinase)在生物化学的广阔舞台中，激酶扮演着一个至关重要的角色，它们是酶家族中的明星成员，专司于能量密集的化学反应——磷酸化。简单来说，激酶就像是生物化学中的"磷酸转移大师"，它们在分子间穿梭，如同接力赛中的接力手，将高能的ATP分子的磷酸基团传...
The heme-regulated eukaryotic initiation factor 2α (eIF2α) kinase, also known as heme-regulated inhibitor (HRI), detects misfolded proteins and induces cytoprotective response to stress, mainly caused by heme-shortage. The nucleoside triphosphate ATP serves as the main donor of phosphate for the...
因此,突变型激酶(Mutant Kinase)很快成为重要的药物靶点,并成为药物发现和开发工作的重点(2)。 图片来源:SignalChem 新格诺康 参考资料 1. Kumar R et al., CancerDR: cancer drug resistance database. Sci Rep. 2013;3:1445. doi: 10.1038/srep01445. 1. Kumar R 等人,CancerDR:癌症耐药资料库,Sci Rep,...
Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity. Mol. Cell 7, 1047–1057 (2001). Article PubMed CAS Google Scholar Zhao, Y. & Shao, F. Diverse mechanisms for inflammasome sensing of cytosolic bacteria and bacterial virulence. Curr. ...
Protein Kinase C–Induced Changes in the Stoichiometry of ATP Binding Activate Cardiac ATP-Sensitive K+ Channels A Possible Mechanistic Link to Ischemic Pr... Activation of both ATP-sensitive K+ (KATP) channels and the enzyme () has been associated with the cardioprotective response of ischemic ...
Significantly, mucin gene expression was elevated in breeding-colored males, contrasting with the upregulation of two ATP-related genes observed in sneaker-morph males. There was a slight indication of elevated sperm velocity among sneaker-morph males, but no alteration in sperm motility was found....
Physiological concentrations of ATP prevent formation of RAF kinase-domain (RAFKD) dimers that are critical for activity. Here we present a 2.9-Å-resolution crystal structure of human BRAFKD in complex with MEK and the ATP analog AMP-PCP, revealing interactions between BRAF and ATP that ...
We present here the first identification of a serine/threonine kinase that possesses an RNP-type RNA recognition motif: KIS. We originally isolated KIS in a two-hybrid screen through its interaction with stathmin, a small phosphoprotein proposed to play a general role in the relay and integration...
a kinase-dead knock-in mutation in mtor leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice一个kinase-dead敲入mtor的突变会导致早期胚胎杀伤力,可有可无的杂合的老鼠的免疫系统.pdf 关闭预览 想预览更多内容,点击免费在线预览全文 免费在线预览全文 ...
3e, f). Moreover, western blot analysis revealed a decreased level of the c-Myc protein, a key cell cycle regulator [79, 80], and a reduction in phosphorylation of nutrient-sensitive p70 S6 kinase (p < 0.05) in both HT-29 and HCT116 cell lines (Fig. 3g). The p70 S6K is ...