We further determined the crystal structure of the kinase domain of PpkA (PpkA-294). The structure of PpkA-294 was determined in its apo form to a 1.6?? resolution as well as in complex with ATP to a 1.41?? resolution and with an ATP analogue AMP-PCP to a 1.45?? res...
This structure will facilitate further biochemical studies and structure-based design of drugs related to pyridoxal kinase.Peng Cao aYong Gong aLin Tang aYun-Chung Leung bTao Jiang aJournal of Structural BiologyCAO P., GONG Y., TANG L., LEUNG Y.C. & JIANG T. 2006: Crystal structure of ...
Choline kinase catalyzes the ATP-dependent phosphorylation of choline, the first committed step in the CDP-choline pathway for the biosynthesis of phosphatidylcholine. The 2.0 crystal structure of a choline kinase from C. elegans (CKA-2) reveals that the enzyme is a homodimeric protein with each ...
Dephosphocoenzyme A kinase (DCK) catalyzes phosphorylation in the final step of coenzyme A (CoA) biosynthesis. In this phosphorylation process, domain move... A Seto,K Murayama,M Toyama,... - 《Proteins-structure Function & Bioinformatics》 被引量: 34发表: 2010年 Structure of ATP-dependent ...
Crystal structure of human Vaccinia-related kinase 1 (VRK1) in complex with AMP-PNP, a non-hydrolysable ATP analog.kinasemitotic kinasevaccinia-related kinaseVRK1adenosine triphosphateATPVaccinia-related kinase 1 (VRK1), a serine/threonine mitotic kinase, is widely over-expressed in dividing cells ...
kinase (CysND), which converts ATP and sulfate to AMP and adenosine 5′-phosphosulfate (APS). The APS is transformed into 3′-phosphoadenosine 5′-phosphosulfate (PAPS) by adenylyl-sulfate kinase (CysC), and then reduced to sulfite (SO32−) by phosphoadenosine phosphosulfate reductase (CysH)...
Crystal structure of cyclin-dependent kinase 2 The crystal structures of the human CDK2 apoenzyme and its Mg2+ ATP complex have been determined to 2.4angstrom resolution. The structure is bi-lobate, ... HL De Bondt,J Rosenblatt,J Jancarik,... - 《Nature》 被引量: 2105发表: 1993年 Crysta...
This site is conserved in humans although Polo-like kinase 1 has been identified as the relevant kinase in place of CK228. The structure of the adaptor Skp1 and its function as a component of the SCF complexes has been well-characterised29,30. Skp1 has an N-terminal BTB/POZ domain31 ...
Crystal structure of an uncharacterized sugar kinase PH1459 from pyrococcus horikoshii G Kumar,S Eswaramoorthy,S Burley,... 被引量: 0发表: 2008年 Crystal structure of the putative RNA methyltransferase PH1948 from Pyrococcus horikoshii, in complex with the copurified S-adenosyl-L-homocysteine Gao...
The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue Nature, 375 (1995), pp. 554-560 View in ScopusGoogle Scholar 39 J Goldberg Structural and functional analysis of the ARF1–ARFGAP complex reveals a rol...