The structure presented here should aid in the design of inhibitors specific to TAO2 and related kinases.VIP生物化学与生物物理学报(英文版)Zhou TJ, Sun LG, Gao Y, Goldsmith EJ. Crystal structure of the MAP3K TAO2 kinase domain bound by an inhibitor staurosporine. Acta Biochim Biophys Sin (...
Crystal structure of the p38α MAP kinase in complex with a docking peptide from TAB1 Abstract The mitogen-activated protein kinase (MAPK) p38α is a key regulator in many cellular processes, whose activity is tightly regulated by upstream kinases, phosphatases and other regulators. Transforming gr...
The structure thus reveals a protein that has evolved through a process of gene duplication, mutation and fusion, into an enzyme with high and unusual specificity. 展开 关键词: Bacillus anthracis Zinc Macromolecular Substances Mitogen-Activated Protein Kinase Kinases MAP Kinase Kinase 2 Bacterial ...
apoptosis JNK MAP kinase X-ray structure Introduction Mammalian cells respond to extracellular stimuli by activating members of the mitogen-activated protein (MAP) kinase family, which include the extracellular signal regulated kinases (ERKs), the p38 MAP kinases and the c-Jun N-terminal kinases (JN...
(A) Domain structure of the human C4. The primary structure for the precursor C4 protein consists of 1744 amino acids with a signal peptide of 19 amino acids that is removed upon secretion. The Pro-C4 protein is made up of 13 domains that include eight α2-macroglobulin-like domains (...
The overall structure of MPK6 contains a two-domain structure that is common to protein kinases (Fig. 2)33. The N-lobe (residues 32–147 and 360–394) contains eight β -strands (β 1 to β 5, β 0L0, β 1L0, and β 2L0) and two α -helices (α C ...
We also determined the structure of the catalytically... J Xiao,JL Engel,Z Ji,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 0发表: 2011年 Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis This ...
The high-resolution (1.85 Å) crystal structure of human ASNS has enabled us to identify a cluster of negatively charged side chains in the synthetase domain that plays a key role in inhibitor binding. Comparing this structure with those of evolutionarily related AMP-forming enzymes provides ...
VEGFRs are receptor tyrosine kinases that, like the platelet-derived growth factor receptors (PDGFRs), contain a large insert within the kinase domain. Results: We report here the generation, kinetic characterization, and 2.4 Å crystal structure of the catalytic kinase domain of VEGF receptor 2...
Figure 1. Structure Solution Experimental electron density map around an AMP-PNP molecule (native-1, see Experimental Procedures) contoured at 1.2 σ. Superimposed is the final atomic model. The map was calculated at a resolution of 2.7 Å with purely experimental phases after density modification...