Bendamustine is an antineoplastic drug with structural similarities to alkylating agents and purine analogs approved for the treatment of CLL and other indolent B-cell lymphoid malignancies by the US Food and Drug Administration (FDA) in 2008 and European Medicines Agency (EMA) in 2010. For many ...
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Doxil is thetrade name for doxorubicin liposomal. In some cases, health care professionals may use the trade name doxil when referring to the generic drug name doxorubicin liposomal. Drug type: Doxorubicin (liposomal) is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. ...
Microtubule polymerization is usually considered as the upstream of apoptotic cell death induced by taxanes, but recently published studies provide more insights into the mechanisms responsible for the antineoplastic effect of taxanes. In this study, we figure out the role of the stress-related PERK/...
Auranofin (AF), a gold (I)-containing phosphine compound, is being investigated for oncological application as a repurposed drug. We show here that 4~5 µM AF induces paraptosis, a non-apoptotic cell death mode characterized by dilation of the endop
Mastoparan acted as a chemosensitizing agent since low doses of Mastoparan reduced the EC50 of etoposide by approximately 2-fold (Fig. 5A). In contrast, Mastoparan did not significantly alter vinblastine-mediated cytotoxicity (i.e., toxicity only increased by 10%; ∆ IC50 ~ 1.2-fold; Fig...
Which antibiotic is used as antineoplastic agent? The antineoplastic antibiotics are products of Streptomyces. The important drugs in this group includeactinomycin D (dactinomycin), doxorubicin, mitoxantrone, and bleomycin. Drugs less commonly used include daunorubicin, mithramycin, and mitomycin. ...
Gastrointestinal mucosal injury (mucositis), commonly affecting the oral cavity, is a clinically significant yet incompletely understood complication of cancer chemotherapy. Although antineoplastic cytotoxicity constitutes the primary injury trigger, the interaction of oral microbial commensals with mucosal tissues...
Answer and Explanation:1 A corticosteroid drug is a medicine used to treat inflammation present in some areas of the body. Corticosteroid drugs decrease swelling, itching,... Learn more about this topic: Therapeutic Response to Oral Corticosteroids ...
LY011 is an anti-CLDN18.2 third-generation CAR-T-cell product prepared from allogeneic T lymphocytes that have been genetically modified to target the tumor-associated antigen (TAA) CLDN18.2 by using lentivirus vector technology with potential immunostimulating and antineoplastic activities. Upon admini...