A strong correlation (P = 0.001) has emerged between p53 alterations and response to chemotherapy; only one (14%) of seven patients who had a pathological complete response to antiblastic drugs showed p53 aberrations, whereas 18 (82%) of 22 cases with partial response and all of the four ...
Many new useful drugs are required for chemotherapy and agriculture to continuously cure and feed an increasing population. Careful reconsideration of mediocre decisions is necessary. Scientists are heading in the right direction with respect to their way of thinking, and the minds of the other ...
Lung cancer is currently the leading cause of death by cancer worldwide [1], rendering this disease a major public health problem. Over 80% of incidence corresponds to non-small cell lung cancer (NSCLC), and the main first-line treatment for advanced stages is cisplatin chemotherapy [2,3]....
1.4. Risk of infections due to specific chemotherapy agents Alkylating agents and Anthracyclines Anthracyclines (idarubicin, daunorubicin, and doxorubicin) are unique among chemotherapeutic drugs in that they induce apoptosis of hematopoietic cell lines (124) in the Infections in Leukemia 343 G0-G1 ...
These antineoplastic agents have been investigated in clinical trials for malignancies from many tissues, including breast, gynecologic, gastrointestinal, lung and melanoma, alone or in association with hormonal therapies, EGFR inhibitors, and cyto‐ toxic drugs [3, 19, 26, 27]. The efficacy of ...
They differ in molecular weight, pattern of expression, function, and their apparent sensitivity to antineoplastic drugs. The β isoforms show no dependency on cell cycle phase, and its function is still largely unknown; in contrast, topo IIα expression is cell cycle-dependent (G2/M) and ...
Pemetrexed is an antineoplastic chemotherapy drug. It is used in the treatment of malignant mesothelioma and locally advanced or metastatic nonsquamous non-small cell lung cancer. - Available as a ready to dilute liquid formulation - does not require reconstitution from powder saving time and costs....
Laboratory tests: Patients with impaired bone marrow function should be cautious when using medication. When combined with other anti-tumor drugs for combined or sequential chemotherapy, the accumulation of bone marrow suppression should be considered. Before each patient receives gemcitabine treatment, the...
Consequently, HDAC inhibitors have entered late-phase clinical trials as new antineoplastic drugs. However, little is known about expression and function of specific HDAC isoforms in human tumours including prostate cancer. We investigated the expression of class I HDACs in 192 prostate carcinomas by...
Molecular target antineoplastic drugs have often provided a paradigm shift in cancer therapy and currently hold a prominent position in cancer therapeutic strategies. While these drugs have clinical benefits, the toxicity profile of these drugs is different from that of conventional cytotoxic chemotherapy....