The article presents information on a study comparing the effectiveness of an antineoplastic agent called imatinib with chemotherapy for acute lymphoblastic leukemia (ALL) in older people conducted in Germany. According to the findings, the agent is more effective than multiagent chemotherapy induction ...
The antineoplastic drug VRB, administered orally as a monotherapy, has been the subject of the most phase II research for non-small cell lung cancer (NSCLC). For patients deemed unsuitable for platinum-based treatments or who were already getting multiple medications, the most popular schedule was...
6-Mercaptopurine (6-MP): antineoplastic and immunosuppressive agent 6-Thioguanine Azathioprine (immunosuppressant): undergoes nonenzymatic reduction into 6-MP Fludarabine Cladribine6-MercaptopurineMechanism of action: Metabolized by hypoxanthine-guanine phosphoribosyl transferase (HGPRTase) into a metabolite thio...
R. Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations. J. Transl. Med. 7, 58 (2009). Article CAS PubMed PubMed Central Google Scholar Kaneno, R. et al. Chemotherapeutic agents in low noncytotoxic concentrations increase immunogenicity ...
During the study, no other antineoplastic therapies including chemotherapy, immunotherapy, radiotherapy, or experimental agents were allowed. Patients who required specific antitumor therapy to treat recurrent disease were withdrawn from the study. Assessments Prior to enrollment in the study, all patients ...
cell exposure constitute are effective inPCeradication. A major downside ofintraperitoneal chemotherapy, however, is that drugs cannot penetrate inside the depth of the tumor deposits. In order to address this issue, hyperthermic solution forperitoneal lavageare associated to antineoplastic drugs f...
Cisplatin remains the best studied and most active single agent in patients with squamous cell carcinoma of the cervix. While a number of other agents ... T Thigpen,R Vance,B Lambuth,... - 《Cancer》 被引量: 179发表: 1987年 Prognostic factors in surgically treated small cell cervical carci...
Irinotecan is one of the newer cytostatic agents which have a clinically relevant antineoplastic activity in colorectal cancer. As single-agent irinotecan induced an overall objective response rate of about 25% in chemonaive patients and of about 13% in 5-fluorouracil(5-FU)-pretreated patients. In...
Intraperitoneal antineoplastic drug delivery: rationale and results. Lancet Oncol. 2003;4:277–283. 12. Casper ES, Kelsen DP, Alcock NW, Lewis JL, Jr. Ip cisplatin in patients with malignant ascites: pharmacokinetic evaluation and comparison with the IV route. Cancer Treat Rep. 1983;67:235–...
Ohyama K, Koike D, Odake Y et al. Antineoplastic effect of UFT therapy (uracil-FT-207 combination therapy) on experimental pancreatic cancer transplanted in the pancreas and subcutaneous region. Jpn J Cancer Chemother 1982;9:2168-2174.