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They found that the exosome-mediated transfer of CRNDE from M2-like macrophages to GC cells could inhibit PTEN expression, thereby reducing the susceptibility of GC cells to DDP. Silencing lncRNA CRNDE expression in M2 exosomes effectively reversed the DDP resistance in GC cells induced by M2 ...
Exosome-mediated delivery of siRNA in vitro and in vivo. Nat Protoc. 2012;7:2112–26. Article CAS PubMed Google Scholar Xing X, Ai C, Wang T, Li Y, Liu H, Hu P, et al. The first high-quality reference genome of sika deer provides insights for high-tannin adaptation. Genomics ...
Exo'One is an exosome product that contains 2 billion highly purified Exosomes derived from human stem cells, which provide a safe and powerful regenerating effect and the highest permeability rate and delivery of substances directly to...
For example, several enriched pathways involve exosome activity, which has been implicated in signaling between tumor cells and contributes to tumor progression56. In addition, both the birabresib and combination treatment groups have an upregulation in angiogenesis-related cell migration, suggesting ...
P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice. Mol Neurodegener. 2020;15:47. Article CAS PubMed PubMed Central Google Scholar Abounit S, Bousset L, Loria F, Zhu S, de Chaumont F, Pieri L, Olivo-Marin JC, Melki R, Zurzolo C. ...
For example, several enriched pathways involve exosome activity, which has been implicated in signaling between tumor cells and contributes to tumor progression56. In addition, both the birabresib and combination treatment groups have an upregulation in angiogenesis-related cell migration, suggesting ...
F and G, efficient encapsulation of mRNA by lipid-mediated exosome loading. F, gel-like image of RNA markers and samples separated on an RNA chip in an Agilent Bioanalyzer. Data is presented, left to right, for Antares2 mRNA, three separate mRNA-loaded exosome preparations, and the RNA ...
A universal characteristic of eukaryotic transcription is that the promoter recruits RNA polymerase II (RNAPII) to produce both precursor mRNAs (pre-mRNAs) and short unstable promoter upstream transcripts (PROMPTs) toward the opposite direction. However, how the transcription machinery selects the correct...
The therapeutic options for Alzheimer’s disease (AD) are limited, underscoring the critical need for finding an effective regulator of Aβ42 production. In this study, with 489 human postmortem brains, we revealed that homotrimer G protein subunit gamma 5 (GNG5) expression is upregulated in ...