the nucleic acids in the cells—DNAand RNA—have risen in prominence amongst the molecules of life. The race to solve the structure ofDNAis famous in the annals of scientific discovery, and decoding its secrets has earned many scientists their Nobel Prizes. ...
15N] labeled amino acids would donate the labeled nitrogen to unlabeled αKG to generate [15N] glutamate, or [13C5]αKG would be aminated from an unlabeled amino acid to generate [13C5] glutamate (Fig. 4d). Note that reverse transamination with [13...
1d). We also used a previously published RNA-seq dataset from a cardiomyocyte model of SARS-CoV-2 infection11. We saw decreased expression of the αKGC complex members OGDHL and DLD in the SARS-CoV-2 infected cardiomyocytes, which suggests the oxidative TCA cycle is also impaired in these ...
RNA is a biological macromolecule that serves a number of different functions. Messenger RNA (mRNA), transcribed from DNA, serves as a template for synthesis of proteins. Protein synthesis is carried out by ribosomes, which consist of ribosomal RNA (rRNA) and proteins. Amino acids for protein ...
DNA is one of the nucleic acids, information-containing molecules in the cell (ribonucleic acid, or RNA, is the other nucleic acid). DNA is found in the nucleus of every human cell. The information in DNA: guides the cell (along with RNA) in making new proteins that determine all our ...
mRNA, which stands for messenger RNA, is an important molecule in the process of protein synthesis. mRNA carries a copy of a gene from DNA and is used as a template for translation into a sequence of amino acids. Answer and Explanation: ...
an enzyme zooms in and constructs a new RNA molecule whose sequence mirrors that of the unzipped gene. This RNA copy, called messenger RNA (mRNA), tells the cell's protein-making machinery whichamino acidsto string together into a protein, according to "Biochemistry" (W. H. Freeman and Com...
The thylakoid transit peptide of tobacco oxygen-evolving enhancer protein contains a minimal ten amino acid sequences for thylakoid lumen transports. This ten amino acids do not contain twin-arginine, which is required for typical chloroplast lumen translocation. Abstract Chloroplasts are intracellular org...
DNA:DNA:RNA triplexes that are formed through Hoogsteen base-pairing of the RNA in the major groove of the DNA duplex have been observed in vitro, but the extent to which these interactions occur in cells and how they impact cellular functions remains elusive. Using a combination of bioinforma...
Tumour cell plasticity is a major barrier to the efficacy of targeted cancer therapies but the mechanisms that mediate it are poorly understood. Here, we identify dysregulated RNA splicing as a key driver of tumour cell dedifferentiation in colorectal ca