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The selective genetic removal of APOE4 from neurons led to a significant reduction in tau pathology, gliosis, neurodegeneration, neuronal hyperexcitability and myelin deficits. Single-nucleus RNA-sequencing revealed that the removal of neuronal APOE4 greatly diminished neurodegenerative disease-associated ...
In both humans and mice, vitamin B12is used as a cofactor by only two enzymes: methionine synthase (MS) and methylmalonyl-CoA mutase (MUT)26. MS uses B12as a cofactor to regenerate methionine (Met) from homocysteine (Hcy), forming an integral part of one-carbon (1C) metabolism (Fig.2a...
The nucleic acid sequence is not present in a recombinant viral vector. The nucleic acid sequence is expressed in the subject to provide the influenza virus M2 antigen in an amount sufficient to elicit an immune response... HAYNES Joel R.,MACKLIN Michael D.,PAYNE Lendon G. - WO 被引量: ...
a Strong immunostaining of TMED3; b moderate staining of TMED3; c weak staining of TMED3; d negative staining of TMED3 in breast cancer tissue; e negative staining of TMED3 in normal breast tissue; f moderate staining of TMED3 in the duct of normal breast tissue. Scale bar stands for ...
pathogen associated molecular patterns PK primary keratinocytes TNCB trinitrochlorobenzene Introduction The skin protects us from our environment and is therefore constantly subjected to microbial, chemical, and physical insults that ultimately result in the generation of non-self antigens. Accordingly, the...
HCMV is an opportunistic pathogen that belongs to the beta herpes virus subfamily[28]. It is highly species-specific and spreads only from person to person. HCMV infection is characterized by susceptibility, persistence, and repetition, and it can infect people of any age. Close contact with ...
8). PD-L2 is predominantly expressed by dendritic cells, macrophages and other antigen-presenting cells. Interestingly, PD-L2 is critical for the function of tolerogenic dendritic cells9. Additionally, in the context of cancer, cancer-associated fibroblasts can express PD-L2 and contribute to an ...
(Fig.5e). No differences were observed in the density of TSPO+ astrocytes inAppNL-G-Fat 10 weeks, although a small (relative to that with microglia) increase was observed at 28 weeks (Fig.5f). Finally, we then quantified TSPO+ area in microglia and astrocytes as an index of TSPO ...