Antigen-antibody reaction: A reaction between a molecule on pathogen (antigen) and a specific Y-shaped protein from white blood cell (antibody). Biomarker diagnosis: A determination of a disease by the biomolecules which indicates the disease state. ...
Pattern-recognition receptors (PRR): refers to receptors that bind to pathogen-associated molecular patterns (PAMP). Plasma cell: antibody-producing B cell that has reached its state of maximum differentiation. Regulatory T cells(Treg): population of T cells capable of inhibiting the immune responses...
All mice were bred and maintained under specific pathogen-free conditions. Cell lines MC38 mouse colon carcinoma cells and HCT116 human colon cancer cells were obtained from Cell Resource Center, Peking Union Medical College (PCRC) and maintained in our lab. B16F10 mouse melanoma cells, LLC ...
infection showed inhibitory activity against intracellular growth of BCG andM. tuberculosisin THP-1 macrophages9. These observations suggest that protective antibody responses can be generated during active TB disease. Recently, a thorough analysis of IgG/IgA memory B-cell repertoire from an occupationall...
Mice were housed in the Animal Facility at the Department of Biomedicine, Aarhus University, Denmark, under specific pathogen-free (SPF) conditions in individually ventilated cages at ambient temperature of 20–22 °C and ambient humidity, on a 12-h light/dark cycle with standard chow and ...
The mice were bred and maintained in a specific pathogen-free (SPF) environment in good health. Sequence sources and cloning construction For mRNA vaccine design, the sequences of six MPV surface antigens, A35R, B6R, A29L, E8L, H3L, and M1R, were obtained from the monkeypox virus ...
Several examples of HLA alleles are associated with more than one disease with completely different target tissues and pathogeneses, which defies the notion that antigen presentation should be specific for both the antigen and the presenting HLA molecule. Examples of such HLA alleles are HLA-DRB1*...
Studying transfer of maternal IgG to specific pathogens throughout pregnancy has been challenging; not only because of difficulties in obtaining samples, but also because not all women have antibodies (Abs) to the pathogen or allergen under investigation. The latter problem is eliminated in areas whe...
defined herein will generally function in the same way. The antibody according to the present invention is capable of binding to the immunodominant polypeptides derived fromM. suisand related species such that the pathogen is significantly reduced or even eliminated after administration of the antibody....
DNA microarrays are increasingly being used to assess mRNA expression profiles associated with host-pathogen interactions. In the TB research field, microarrays have been used to explore changes in gene expression in TB infected macrophages [4, 5]. Also, differences in host responses between tuberculo...