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The tissue-specific self- pathogen is the protective self-antigen: the case of uveitis. J Immunol 2002; 169: 5971-5977.Mizrahi T, Hauben E, Schwartz M. The tissue-specific self-patho- gen is the protective self-antigen: the case of uveitis. J Immunol. 2002;169:5971-5977....
We found PG staining of synovium colocalized with both macrophages and synovial fibroblasts. In seeming contradiction, Schrijver et al. [24]. previously showed localization of PG staining from synovial samples only within cells expressing markers of antigen presentation (HLA-DR, CD40, CD80, CD86) ...
It is also known that post-apoptotic remnants in the germinal centers of lymph nodes can serve as selecting antigens for B cells that have acquired auto-reactivity during the process of somatic mutation.38 IgG auto-antibodies recognizing second- ary necrotic cells (SNEC) or apoptotic cell-...
We demonstrate the utility of deep learning to provide an improved ‘featurization’ of the TCR across multiple human and murine datasets, including improved classification of antigen-specific TCRs and extraction of antigen-specific TCRs from noisy single-cell RNA-Seq and T-cell culture-based ...
A、A clone of lymphocytes have the same immunologic specificity as their parent cells. B、The exposure to antigens causes the gene rearrangement of the receptors of the lymphocytes and thus decides the unique receptor specificity. C、To use serum therapy to treat the infectious diseases established...
2018) and all studies differed in their thresholds for seroprotection, the bacterial antigens detected, and units of measurement, precluding meaningful comparisons (Table 7). All studies used an ELISA-based technique to assess the bacterial antigens, anti-pertussis toxoid (anti-PT) IgG, anti-...
Coronavirus mRNA Vaccines program cells to produce SARS COv-2 Spike Protein Antigens; the immune system responds by producing Antibodies which have an affinity to SPION containing Iron-Oxide; the body becomes magnetically observable (eg ESPIONage) with an On-Off death switch....
promote antigen masking. The work presented here suggests that regulated mRNA decay is a pathogen-specific response to host-temperature stress in cryptococci that promotes adaptation via regulation of transcriptome and translatome reprogramming, and demonstrates a link between temperature adaptation and ...
[10]. A vaccine named Bacillus Calmette Guerin (BCG) was developed againstMycobacterium tuberculosisusing Pasteur vaccinology [11]. However, there are some limitations of Pasteur vaccinology as it does not apply to the pathogens which constantly show mutations in antigens present on surfaces or ...