4. These results indicated that vaginal DCs were the antigen presenting cells which present brucella antigen to naive T lymphocytes, leading to the release of IFN-γ. Brucella spp. is an intracellular pathogen that preferentially infects macrophages. The macrophages in vaginal mucosa of BALB/cmice...
Human monocytes are integral to the innate immune response and pivotal in first-line defenses such as phagocytosis, cytokine and chemokine release, and antigen presentation1. Activation of monocytes is triggered by pattern recognition receptors (PRRs) that sense conserved pathogen-associated molecular patt...
2B). As expected, the results showed that candidate genes of the LPS and PolyI:C stimulations were associated with immune activation signals, such as TNF, NF-κβ, leukocyte migration, and antigen presentation signaling pathways, while candidate genes of the EM stimulation were associated with ...
Difference in Antibody Production to Heterologius Erythrocytes in Conventional, Specific-Pathogen-Free (SPF), Germfree and Antigen-Free Micedoi:10.1111/j.1348-0421.1978.tb00433.xThe expression of antibody-producing capacities against hamster erythrocytes (HRBC), known to be weakly immunogenic in mice...
Genes with twofold difference and P < 0.05 after applying Bonferroni’s correction were considered to be statistically significant. LC–HRMS-based analysis of sar BGC metabolites To determine the secondary metabolite(s) whose production was associated with the sar gene cluster, five fermentation ...
Conversely, administering manganese either intranasally or intravenously significantly increased the number of IFN-γ– and TNF-α‒producing CD8+ T cells and activated NK cells in the tumors, possibly due to an increased maturation and antigen-presenting capacity of antigen-presenting cells. In ...
(2014), including inhibition of phagocytosis, expression of costimulatory molecules, secretion of proinflammatory cytokines, and antigen presentation to T cells, which impairs T cell proliferation. Inhibition of DC responses by tick saliva could be beneficial for tick survival, by dampening the host ...
Childhood Vaccination and Nontargeted Infectious Disease Hospitalization It has been hypothesized that multiple-antigen vaccines, such as measles-mumps-rubella vaccine, or aggregated vaccine exposure could lead to immune dysfunc... Hviid,Anders - 《Jama》 被引量: 41发表: 2005年 Effects of human immuno...
There is considerable variation in the degree of antigenic escape that occurs across pathogens and our results may help to explain the difference in virulence between related pathogens including, potentially, human influenzas. Furthermore, it follows that these pathogens will have a lower R0, with ...
Indeed, links between certain MHC alleles and supertypes (i.e., groups of alleles that show similar antigen-binding properties and are therefore assumed to be functionally similar) and lower parasite load and/or survival have been reported in diverse wildlife species (e.g., Schwensow et al. ...