What is the purpose of an antibody?ImmunoglobulinsAntibodies, the antigen-binding glycoproteins are synthesized exclusively by B-cells and billions of forms, each having a different amino acid sequence and a different antigen-binding site. The simplest antibodies are Y shaped molecules with two ...
We also immunostained with an NG2 antibody to probe for OPCs, which have been suggested to aid the repair of damaged myelin in conditions of CNS injury and neurodegeneration17,56. We observed a significant decrease in the percent OPC coverage area in the hippocampus of PS19-fE4 mice as co...
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Mycobacterium avium subsp. paratuberculosis is a robust and phenotypically versatile pathogen which causes chronic inflammation of the intestine in many sp... Y Aulchenko,D De Koning,C Haley,... 被引量: 640发表: 2007年 Preclinical and Clinical Manifestations of Paratuberculosis (Including Pathology)...
confer a transferable antipathogen effect that could be eradicated by neutralization of interferon-gamma. However, unlike alphabeta T cells, these effects of gammadelta cells showed no evidence of functional immunological memory. These results are directly relevant to coccidiosis, an economically ...
a, Total IgE serum concentrations and numbers of BAL (b) eosinophils and (c) T cells in WT BALB/c mice undergoing a full allergen-exposure protocol using HDM that was depleted using either an isotype control antibody or a monoclonal antibody specific for mite group-13 allergens. d, Numbers...
The specificity of each antibody was confirmed by Western blot analysis of extracts from 293T cells transfected or not with the relevant complementary DNAs. The data presented are representative of at least three independent experiments. Expression at the protein level was confirmed by SDS-PAGE/...
a Strong immunostaining of TMED3; b moderate staining of TMED3; c weak staining of TMED3; d negative staining of TMED3 in breast cancer tissue; e negative staining of TMED3 in normal breast tissue; f moderate staining of TMED3 in the duct of normal breast tissue. Scale bar stands for ...
(18). In addition, passive transfer of a monoclonal antibody specific for CD11b (CR3) inhibits myelomonocytic cells in ananimal modelof inflammation (17). These studies support a role for cell adhesion molecules in the firm attachment of monocyte/macrophages to endothelial cells at inflammatory ...
To assess the physiological importance of LDLR as a CCHFV entry receptor in vivo, we utilized LDLR-deficient mice. Since immune competent mice are resistant to CCHFV infection, we used an anti-IFNAR1 monoclonal antibody (MAR1-5A3) to transiently suppress type I IFN-triggered antiviral effects ...