The NAD(+) kinase (NADK) is the only known enzyme capable of phosphorylating NAD(H) to NADP(H) and therefore it plays a crucial role in maintaining NAD(P)(H) homeostasis. All domains of life contain at least one NADK gene, and the commonly investigated isoforms have been measured, or ...
Casein Kinase II Is a Predominantly Nuclear Enzyme W Krek,GMA Nigg - 《Journal of Cell Biology》 被引量: 0发表: 1992年 Human casein kinase II: structures, genes, expression and requirement in cell growth stimulation. This is in accordance with the finding that CKII is predominantly a ...
The peripheral membrane proteins that are located on the interior surface of the cell membrane provide a foundation for the scaffolding of the cell. These include the cytoskeletal proteins actin and spectrin. An enzyme called protein kinase C is another interior peripheral membrane protein. It initiat...
Creatine kinase, an ATP-generating enzyme, is required for thrombin receptor signaling to the cytoskeleton. Proc Natl Acad Sci U S A 97, 12062-12067.Mahajan, V. B., Pai, K. S., Lau, A., Cunningham, D. D. (2000) Creatine kinase, an ATP-generating enzyme, is required for thrombin...
In Lewy body diseases and multiple system atrophy, α-synuclein is hyperphosphorylated at Ser129, suggesting a role in pathogenesis. Here, we report purification of the protein kinase in rat brain that phosphorylates Ser129 and its identification as casein kinase-2 (CK2). We show that most of...
The quantification of human-derived VEGFA secretion from U87 cell lines was conducted using the enzyme-linked immunosorbent assay (ELISA) kit from Proteintech (#KE00216, China). The procedure was applied in strict accordance with the manufacturer’s protocol provided by the kit. Wound healing and...
Age and sex are major risk factors in Alzheimer’s disease (AD) with a higher incidence of the disease in females. Neuroinflammation, which is a hallmark of AD, contributes to disease pathogenesis and is inexorably linked with inappropriate microglial ac
Staphylococcus aureus (S. aureus) siderophore natural product biosynthesis crystal structure enzyme kinetics kinase kinetics O-phospho-L-serine staphyloferrin virulence factor Introduction Staphylococcus aureus is a prominent human pathogen that also asymptomatically colonizes a proportion of the human populati...
AURKA is predominantly famous as an essential mitotic kinase. Recent findings have also established its critical role in a plethora of other biological processes including ciliogenesis, mitochondrial dynamics, neuronal outgrowth, DNA replication and cell
a methionine adenosyltransferase 2A inhibitor (MAT2Ai; Fig.3a); MAT2A is the enzyme immediately downstream of MS, which converts Met into SAM (Fig.2a). Moreover, directly supplementing only SAM at a high concentration34during reprogramming significantly improved the efficiency of the process, ...