Protein phosphorylation is involved at multiple steps of RNA processing and in the regulation of protein expression. We present here the first identification of a serine/threonine kinase that possesses an RNP-type RNA recognition motif: KIS. We originally isolated KIS in a two-hybrid screen through...
Protein phosphorylation is involved at multiple steps of RNA processing and in the regulation of protein expression. We present here the first identification of a serine/threonine kinase that possesses an RNP-type RNA recognition motif: KIS. We originally isolated KIS in a two-hybrid screen through...
The sympathoadrenergic system and its major effector PKA (protein kinase A) are activated to maintain cardiac output coping with physiological or pathological stressors. If and how PKA plays a role in physiological cardiac hypertrophy (PhCH) and pathological CH (PaCH) are not clear.#Transgenic ...
The human lymphoblast cell line Jurkat is widely used as a model system for studying signal transduction pathways during lymphocyte activation. We report the presence of a potent endogenous inhibitor of protein kinase C (PKC) in the cytosolic fraction of Jurkat cells. This inhibitor is not diffusib...
摘要原文 Protein kinase D (PKD/PKCmu immunoprecipitated from either COS-7 cells or Jurkat T lymphocytes transiently transfected with a constitutively active mutant of PKCtheta AE (PKCthetaAE) exhibited a marked increase in basal activity. In contrast, coexpression of constitutively active mutant of ...
AXL receptor tyrosine kinase is overexpressed in triple-negative breast cancer (TNBC), and has a function in cancer progression and metastases. However, the mechanism underlying AXL gene regulation in TNBC remains unknown. In this study, the involvement of protein kinase C α (PKCα) in the exp...
A Protein Kinase is Located in the Micellar Fraction of Fresh Pasteurized Skimmed Farm MilkA Protein Kinase is Located in the Micellar Fraction of Fresh Pasteurized Skimmed Farm Milkmilkcaseinsprotein kinasephosphorylationRecombinant protein kinase CK2 from the yeast g milk proteins, i.e., 0.26 P/...
Protein Kinase G is a key regulator of murine white adipogenesis Open Access Available under Open Access This content is freely available online to anyone, anywhere at any time. Journal BMC Pharmacology 11:P48 Online Date August 2011 DOI 10.1186/1471-2210-11-S1-P48 Online ISSN 1471-2210 ...
The conserved cAMP-dependent protein kinase (PKA) is composed of the regulatory and catalytic subunits and acts as the central component of the cAMP signaling pathway. In the human fungal pathogenCandida albicans, the PKA regulatory subunit Bcy1 plays a critical role in the regulation of cell dif...
protein degradation protein kinase C (PKC) protein phosphorylation signal transduction PKCα, desensitization Introduction Protein kinase C (PKC) α is a signaling protein that regulates important events in self-renewing tissues, including progression through the cell cycle, differentiation, and cell surviv...