consisting of N- and C-terminal lobes separated by a hinge/linker that creates an ATP-accommodating cleft and site of phospho-transfer toward a peptide substrate. The fundamental structure and major regulatory elements of aprotein kinase, usingprotein kinase A(PKA) as atemplate, is presented in...
Protein Kinase C: Structure, Function, and RegulationEhrlichplasma membrane redoxcGMP, Ca2Newton AC.doi:10.1074/jbc.270.48.28495NewtonA. C.Journal of Biological Chemistry
大多数激酶同时作用于丝氨酸和苏氨酸 (称为丝氨酸/苏氨酸激酶，protein serine/threonine kinases，PSKs)。PSKs 种类较多，包括蛋白激酶 A (protein kinase A, PKA)，蛋白激酶 C (protein kinase C, PKC)，钙/钙调素依赖性蛋白激酶 (Calcium/calmodulin dependent protein kinase, CaMK)，G 蛋白偶联受体激酶，cGMP...
Structure and Function of the Protein Kinase R Curr Top Microbiol Immunol. 2007;316:253–92.Sadler, A., Williams, B., 2007. Structure and function of the protein kinase R. In: Interferon: The ... A.J. Sadler,B.R.G. Williams - 《Curr Top Microbiol Immunol》 被引量: 343发表: 2007...
1, the catalytic domain of DAPK has amino acid sequence similarity to the corresponding region of the MLCK catalytic domain (∼44% identity) and the phosphorylase kinase catalytic domain (33% identity). However, a crystal structure of the MLCK catalytic domain is not available, whereas a high...
Higher plants contain a multigene family encoding proteins that share a highly conserved catalytic protein kinase domain about 70% identical to SHAGGY protein kinase (SGG) and glycogen synthase kinase-3 (GSK-3), respectively, from Drosophila and mammals. In this study we have characterized the str...
AlphaFold can predict the structure of single- and multiple-chain proteins with very high accuracy. However, the accuracy decreases with the number of chains, and the available GPU memory limits the size of protein complexes which can be predicted. Here
The regulation of L-type Ca2+ channels by protein kinase A (PKA) represents a crucial element within cardiac, skeletal muscle and neurological systems. Although much work has been done to understand this regulation in cardiac CaV1.2 Ca2+ channels, relati
(epinephrine and norepinephrine). Furthermore, CA activates protein kinase A (PKA) via adrenoreceptors (ARs), such as β3-AR. Subsequently, PKA significantly impacts UCP1 activity by orchestrating various cellular processes. These include AIDA, a protein containing a C2 domain known for its ...
Arabidopsis calcium-dependent protein kinase CPK32 interacts with ABF4, a transcriptional regulator of abscisic acid-responsive gene expression, and modulates its activity. Plant Physiol. 2005;139:1750–61. PubMed PubMed Central CAS Google Scholar Coca M, San Segundo B. AtCPK1 calcium-dependent ...