AKAPs AKAPs are a diverse family of scaffold proteins that form multi-protein complexes, integrating 3'-5'-cyclic adenosine monophosphate (cAMP) -signaling with protein kinases, phosphatases, and other effector proteins. AKAP Historical Background Early physiology experiments illustrated that stimulation...
A central feature of cAMP signaling is the compartmentalization via A-kinase anchoring proteins (AKAPs). Functional studies on the role of AKAPs and their therapeutic value to target the process of EMT in the lung are still lacking. Methods TGF-β 1 and cigarette smoke were used to induce ...
Objective To investigate promoter CpG methylation status of A-kinase anchoring protein 12(AKAP12) in acute lymphoblastic leukemia in children and analyze the association between the methylation of AKAP12 and clinicopathological features. 目的探讨儿童急性淋巴细胞白血病(ALL)中A激酶锚定蛋白12(AKAP12)基因...
Engineering A-kinase Anchoring Protein (AKAP)-selective Regulatory Subunits of Protein Kinase A (PKA) through Structure-based Phage Selection * PKA is retained within distinct subcellular environments by the association of its regulatory type II (RII) subunits with A-kinase anchoring proteins (AKAP.....
A-kinase anchoring proteins: protein kinase A and beyond. Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger mediated signaling events. Localization of the... AS Edwards,JD Scott - 《Current Opinion in Cell Biology》 被引量: 547发表: 2000...
上海玉博生物科技有限公司 主要致力于“Anti-AKAP95/AKAP8(A-kinase Anchoring Protein 95) 蛋白激酶A锚定蛋白95抗体 yb-1473R”的生产销售。多年的“Anti-AKAP95/AKAP8(A-kinase Anchoring Protein 95) 蛋白激酶A锚定蛋白95抗体 yb-1473R”生产与销售的经验,与各行业新
AKAP7 is a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins which bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular sections. AKAP7 is expressed in heart, brain, pancreas...
2) A-kinase anchoring protein 12 A激酶锚定蛋白12 1. Objective To investigate promoter CpG methylation status of A-kinase anchoring protein 12(AKAP12) in acute lymphoblastic leukemia in children and analyze the association between the methylation of AKAP12 and clinicopathological features. 目的探讨...
Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). In the past year there have been many advances in our understanding of AKAPs, particularly in the field of the functional consequences of PKA ...
Objective To investigate promoter CpG methylation status of A-kinase anchoring protein 12(AKAP12) in acute lymphoblastic leukemia in children and analyze the association between the methylation of AKAP12 and clinicopathological features. 目的探讨儿童急性淋巴细胞白血病(ALL)中A激酶锚定蛋白12(AKAP12)基因...