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Moreover, the high molecular heterogeneity of GBM tumors, exemplified by unevenly distributed amplifications of EGFR and PDGFR, challenges the effectiveness of receptor tyrosine kinase inhibitors. Analysis of The Cancer Genome Atlas (TCGA) and single-cell RNA-seq further reveals substantial heterogeneity...
PurposeTo evaluate if the use of an intra-aortic balloon pump (IABP) during cardioplegic arrest improves body perfusion.Methods158 coronary artery bypass graft (CABG) patients were randomized to linear cardiopulmonary bypass (CPB) (n=71, Group A) or automatic 80 bpm intra-aortic ballon pump (...
CKD is defined as the presence of kidney damage or an estimated glomerular filtration rate (eGFR) less than 60 mL/min per 1.73 m2, persisting for 3 months or more.3 Symptoms Early chronic kidney disease has no signs or symptoms as kidney function deteriorates slowly over time. ...
Breast cancer is the most common female cancerous disease and the second most cause of cancer death in women. About 20–30% of these tumors exhibit an amplification of the HER2/ErbB2 receptor, which is coupled to a more aggressive and invasive growth of
ANA induced a decrease of EGFR levels on LNCaP, DU145, and PC3 prostatic cancer cells by acting through cannabinoid CB1 receptor subtype and this leaded to an inhibition of the EGF-stimulated growth of these cells. Moreover, the G1 arrest of metastatic DU145 and PC3 growth was accompanied ...
(A) AURKA phosphorylates RPS6KB1 is mutant K-Ras expressing cells. AURKA colocalizes and directly phosphorylates RPS6KB1 at T389 in K-Ras mutant gastrointestinal cancer cells leading to increased proliferation and survival. (B) AURKA activates EGFR signaling via SDCBP. AURKA stabilizes SDCBP by...
As a pathologically and genetically heterogeneous disease, RCC falls into at least four subtypes, including clear-cell, a predominant type (about 80%) and others (papillary, chromophobe, and collecting duct carcinomas). In clear cell renal cell carcinoma (ccRCC), inactivation of the von Hippel ...
It is therefore advisable that, before to taking position on which equation should be used for estimating glomerular filtration rate (eGFR) (e.g., Chronic Kidney Disease Epidemiology Consortium 2009 vs. 2021 version), the international professional bodies more strongly support the choice of selective...
1A). This patterning relies on the intersection of epidermal growth factor receptor (EGFR) and bone morphogenetic protein (BMP) pathways within the FC epithelium of each egg chamber, providing a combinatorial framework for establishing precise spatial and temporal gene-expression patterns (summarized in...